Multiple carcinoids of the duodenum accompanied by type I familial multiple endocrine neoplasia

Surgery Today
K YazawaJ Amano

Abstract

A case of multiple carcinoid tumors of the duodenum accompanied by familial multiple endocrine neoplasia is reported. A 46-year-old man with duodenal polyps discovered during a mass screening was followed up for 5 years. In August 1994, a histological examination revealed carcinoid tumors, and he was thus referred to our hospital for surgery. He underwent a parathyroidectomy and cholecystectomy for primary hyperparathyroidism and cholecystolithiasis, respectively. The patient's sister had also undergone a parathyroidectomy and distal pancreatectomy for primary hyperparathyroidism and insulinoma of the pancreas. In addition, his two children were also followed up for hypercalcemia. A serum examination of the patient revealed high levels of somatostatin and pancreatic polypeptide, but normal levels of gastrin and serotonin. In November 1994, a pancreaticoduodenectomy with a D2 lymph node dissection was performed. The macroscopic findings of the resected specimen showed multiple polypoid lesions with delles on the top, measuring 3 to 15 mm in size throughout the duodenum. A microscopic examination revealed the tumor to have infiltrated into the submucosa extensively, and an immunohistochemical analysis also demonstrated the tumor ...Continue Reading

References

May 5, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·J AlumetsS Tibblin
Aug 1, 1975·Cancer·J D Godwin
May 1, 1986·The American Journal of Surgical Pathology·Y DayalH J Wolfe
Jul 1, 1987·American Journal of Surgery·Q Y DuhO H Clark
Aug 1, 1985·Gastrointestinal Endoscopy·D E MerrellJ T Garbutt
Feb 1, 1971·American Journal of Surgery·R F WeichertT Drapanas
Aug 1, 1973·Archives of Surgery·J W HofmannS D Wilson
Jan 1, 1972·Annals of Internal Medicine·N SnyderW P Deiss
Jul 1, 1971·Cancer·M J Orloff

Citations

Apr 12, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Won MaHyojin Park

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.