Multiple catalytically active thioredoxin folds: a winning strategy for many functions.

Cellular and Molecular Life Sciences : CMLS
Emilia PedoneSimonetta Bartolucci

Abstract

The Thioredoxin (Trx) fold is a versatile protein scaffold consisting of a four-stranded β-sheet surrounded by three α-helices. Various insertions are possible on this structural theme originating different proteins, which show a variety of functions and specificities. During evolution, the assembly of different Trx fold domains has been used many times to build new multi-domain proteins able to perform a large number of catalytic functions. To clarify the interaction mode of the different Trx domains within a multi-domain structure and how their combination can affect catalytic performances, in this review, we report on a structural and functional analysis of the most representative proteins containing more than one catalytically active Trx domain: the eukaryotic protein disulfide isomerases (PDIs), the thermophilic protein disulfide oxidoreductases (PDOs) and the hybrid peroxiredoxins (Prxs).

References

Jul 14, 1987·Biochemistry·R A Roth, S B Pierce
Nov 24, 1995·The Journal of Biological Chemistry·M C LaboissiereR T Raines
Mar 15, 1995·Structure·J L Martin
Dec 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C C Wang, C L Tsou
Apr 15, 1993·European Journal of Biochemistry·P N VanH D Söling
Dec 15, 1995·Cell·U GrauschopfJ C Bardwell
Feb 7, 1997·The Journal of Biological Chemistry·R W Ruddon, E Bedows
Jul 17, 1998·Nature Structural Biology·R B Freedman
Jun 26, 1999·Journal of Biomolecular NMR·J KemminkN J Darby
Feb 15, 2000·The Journal of Biological Chemistry·A CabibboR Sitia
Jun 8, 2001·The Journal of Biological Chemistry·S P LeeH Z Chae
Jun 12, 2001·Methods in Enzymology·S BartolucciM Rossi
Jun 12, 2001·Methods in Enzymology·B Ren, R Ladenstein
Jul 17, 2001·Current Opinion in Cell Biology·L Ellgaard, A Helenius
Sep 21, 2001·Journal of Biomolecular NMR·L SilvennoinenI Kilpeläinen
Dec 12, 2001·Nature Structural Biology·Einav GrossDeborah Fass
Jan 11, 2002·European Journal of Biochemistry·Aymeric GoyerPaulette Decottignies

❮ Previous
Next ❯

Citations

Jan 6, 2012·Journal of Proteome Research·Walid S MaatyBrian Bothner
May 23, 2012·Antioxidants & Redox Signaling·Samuel LeeRichard T Lee
Nov 22, 2011·Antioxidants & Redox Signaling·Michael C GretesP Andrew Karplus
Mar 19, 2014·Biochemical Pharmacology·Angelika MuchowiczJakub Golab
May 20, 2014·Extremophiles : Life Under Extreme Conditions·Emilia PedoneDanila Limauro
Dec 7, 2013·Extremophiles : Life Under Extreme Conditions·Danila LimauroEmilia Pedone
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ulrich SchweizerClemens Steegborn
Apr 5, 2011·Current Opinion in Structural Biology·Elaine C Meng, Patricia C Babbitt
Sep 22, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Catherine PutontiStefan M Kanzok
Jan 21, 2015·Scientific Reports·Hei-Man Vincent TangDong-Yan Jin
Jan 17, 2017·Fungal Genetics and Biology : FG & B·Mariana SchusterRegine Kahmann
Dec 1, 2013·Botanical Studies·Yu-Ting ChenChi-Tsai Lin
Jan 4, 2020·Free Radical Biology & Medicine·Lisa MullenPietro Ghezzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.