Multiple cerebral microbleeds in hyperacute ischemic stroke: impact on prevalence and severity of early hemorrhagic transformation after thrombolytic treatment

AJR. American Journal of Roentgenology
Ho Sung KimDae Chul Suh

Abstract

The purpose of our study was to assess whether cerebral microbleeds are related to early hemorrhagic transformation after thrombolytic therapy for hyperacute ischemic stroke. The cases of 279 patients with suspected ischemic stroke who underwent MRI including T2*-weighted images were retrospectively evaluated. The inclusion criteria were as follows: imaging performed within 6 hr after symptom onset, presence of territorial infarct of anterior circulation, no history of intracerebral hemorrhage, thrombolytic treatment, and available follow-up MR images. Microbleeds were classified according to number as follows: absent (grade 1, 0 bleeds), mild (grade 2, 1-2 bleeds), moderate (grade 3, 3-10 bleeds), and severe (grade 4, > 10 bleeds). The prevalence and severity of early hemorrhagic transformation after thrombolysis were assessed on follow-up images. Among 279 patients, 65 patients (37 men, 28 women; mean age, 67 years) met the inclusion criteria. Microbleeds were found in 25 patients. Early hemorrhagic transformation occurred in nine of 40 patients without microbleeds (grade 1) and in eight of 25 patients with microbleeds: two of 12 patients with grade 2, three of eight patients with grade 3, and three of five patients with grad...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·T MoulinP Maeder
Jan 1, 1994·European Neurology·T MoulinJ Bogousslavsky
Feb 1, 1996·Journal of the Neurological Sciences·P KapellerI Schafhalter-Zoppoth
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G F HamannG J del Zoppo
Jul 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G J del ZoppoG F Hamann
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·T KinoshitaJ Hatazawa
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·G RoobF Fazekas
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellFernando Vinuela
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Peter D SchellingerWerner Hacke
Jan 14, 2004·Cerebrovascular Diseases·Laurent DerexPaul Trouillas
May 25, 2004·Stroke; a Journal of Cerebral Circulation·Tom JeerakathilCharles DeCarli
Sep 4, 2004·Stroke; a Journal of Cerebral Circulation·Timothy John IngallTeresa J Hengy Christianson

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Citations

Jul 29, 2009·Klinische Neuroradiologie·Thomas Kucinski
Jun 4, 2013·Lancet Neurology·José Álvarez-SabínCarlos S Kase
Oct 2, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Andreas CharidimouDavid J Werring
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Steven M GreenbergEric E Smith
Jul 16, 2010·QJM : Monthly Journal of the Association of Physicians·J BenbassatY Herishanu
Oct 16, 2015·Journal of Stroke·Eun-Jae LeeSteven Warach
Nov 30, 2010·Radiologic Clinics of North America·Mara M Kunst, Pamela W Schaefer
Feb 27, 2010·La Presse médicale·Philippe Goas, Serge Timsit
Sep 15, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Ashkan ShoamaneshOscar R Benavente
Jan 30, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Shenqiang YanMin Lou
Jul 9, 2016·European Radiology·Keon-Joo LeeJae-Kyu Roh
Jan 1, 2012·JRSM Cardiovascular Disease·Puneet KakarDavid J Werring
Aug 15, 2014·Stroke; a Journal of Cerebral Circulation·Steffen DannenbergChristian H Nolte
Sep 26, 2007·Circulation·Larry B Goldstein
Aug 1, 2015·Stroke; a Journal of Cerebral Circulation·Guillaume TurcCatherine Oppenheim
Aug 11, 2016·Stroke; a Journal of Cerebral Circulation·Charlotte ZernaEric E Smith
Dec 17, 2016·Stroke; a Journal of Cerebral Circulation·Eric E SmithUNKNOWN American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Functional Genom
Jun 11, 2015·Journal of Stroke·Beom Joon Kim, Seung-Hoon Lee

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