Abstract
The purpose of our study was to assess whether cerebral microbleeds are related to early hemorrhagic transformation after thrombolytic therapy for hyperacute ischemic stroke. The cases of 279 patients with suspected ischemic stroke who underwent MRI including T2*-weighted images were retrospectively evaluated. The inclusion criteria were as follows: imaging performed within 6 hr after symptom onset, presence of territorial infarct of anterior circulation, no history of intracerebral hemorrhage, thrombolytic treatment, and available follow-up MR images. Microbleeds were classified according to number as follows: absent (grade 1, 0 bleeds), mild (grade 2, 1-2 bleeds), moderate (grade 3, 3-10 bleeds), and severe (grade 4, > 10 bleeds). The prevalence and severity of early hemorrhagic transformation after thrombolysis were assessed on follow-up images. Among 279 patients, 65 patients (37 men, 28 women; mean age, 67 years) met the inclusion criteria. Microbleeds were found in 25 patients. Early hemorrhagic transformation occurred in nine of 40 patients without microbleeds (grade 1) and in eight of 25 patients with microbleeds: two of 12 patients with grade 2, three of eight patients with grade 3, and three of five patients with grad...Continue Reading
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