Multiple chromosomal loci for the babA gene in Helicobacter pylori.

Infection and Immunity
Ewa E HennigT L Cover

Abstract

Helicobacter pylori babA encodes an outer membrane protein that binds to fucosylated Lewis b blood group antigen. We analyzed a panel of 35 H. pylori strains and identified three possible chromosomal loci for babA. There was a significant association between the presence of babA and the presence of cagA (P = 0.0001). Phylogenetic analysis of babA alleles revealed two divergent families of signal sequences. Among 17 strains in which an intact in-frame babA allele was identified, 10 expressed a detectable BabA protein. Expression of a BabA protein and the Lewis b-binding phenotype were not dependent on the chromosomal locus of babA. These data indicate that there is marked heterogeneity among H. pylori strains in babA genetic content and BabA expression.

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Citations

May 9, 2013·Nature Reviews. Microbiology·Nina R SalamaAnne Müller
Apr 27, 2012·Genome Biology and Evolution·Koji YaharaIchizo Kobayashi
Jan 14, 2011·The Journal of Infectious Diseases·Tomoyuki OhnoYoshio Yamaoka
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Nov 3, 2011·Cell Communication and Signaling : CCS·Steffen BackertNicole Tegtmeyer
Jul 31, 2008·World Journal of Gastroenterology : WJG·Yoshio Yamaoka
Jan 1, 2008·Journal of Infection in Developing Countries·Yoshio Yamaoka
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Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Rui M FerreiraCeu Figueiredo
Mar 5, 2013·Journal of Digestive Diseases·Seiji ShiotaYoshio Yamaoka
Apr 24, 2012·Molecular Microbiology·Sarah TalaricoNina R Salama
Apr 26, 2008·Journal of Medical Microbiology·Yoshio Yamaoka
Mar 26, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rita Inés ArmitanoMariana Catalano
Apr 25, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Miguel Angel ChiurilloJosé Luis Ramírez
Oct 13, 2017·Toxins·Mark S McClainTimothy L Cover
Nov 26, 2015·Science Advances·Naim HageFranco H Falcone
Jul 12, 2017·World Journal of Gastroenterology : WJG·Shamshul Ansari, Yoshio Yamaoka
May 31, 2018·PeerJ·Andrés Julián Gutiérrez-EscobarMaria Mercedes Bravo
Jul 27, 2021·Infection and Immunity·M Lorena HarveyTimothy L Cover

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