Multiple Comorbidities and Response to Cardiac Resynchronization Therapy: MADIT-CRT Long-Term Follow-Up

Journal of the American College of Cardiology
Emily P ZeitlerValentina Kutyifa

Abstract

Data regarding cardiac resynchronization therapy (CRT) in patients with multiple comorbidities are limited. This study evaluated the association of multiple comorbidities with the benefits of CRT over implantable cardioverter-defibrillator (ICD) alone. We examined 1,214 MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) study patients with left bundle branch block (LBBB) and 0, 1, 2, or ≥3 comorbidities, including renal dysfunction, hypertension (HTN), diabetes, coronary artery disease, history of atrial arrhythmias, history of ventricular arrhythmias, current smoking, and cerebrovascular accident. In an adjusted analysis, we analyzed risk of heart failure (HF) events or death by comorbidity group in all patients and in patients with CRT with defibrillator (CRT-D) versus ICD. Then we examined percent change in left ventricular (LV) end-diastolic volume, LV end-systolic volume, LV ejection fraction, left atrial volume, and LV dyssynchrony at 1-year in CRT-D patients by comorbidity group. There was an inverse relationship between comorbidity burden and improvements in LV end-systolic volume, LV end-diastolic volume, left ventricular ejection fraction, left atrial volume, and ...Continue Reading

Citations

Mar 7, 2018·Current Treatment Options in Cardiovascular Medicine·Neal A Chatterjee, E Kevin Heist
Nov 15, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Timothy F Christian
Mar 24, 2018·Pacing and Clinical Electrophysiology : PACE·John M FontaineLilian E Ahiable
Jan 13, 2018·Circulation. Arrhythmia and Electrophysiology·Matthew M KalscheurC David Page
Feb 20, 2018·Current Heart Failure Reports·Jad Al DanafAmin Yehya
Dec 28, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francisco LeyvaTian Qiu
Jan 1, 2020·Journal of the American Heart Association·Eyal NofRoy Beinart
Sep 19, 2020·ESC Heart Failure·Jiří KvasničkaEva Čermáková
Jan 5, 2018·European Heart Journal·Lars H LundFrank Ruschitzka
Jul 26, 2019·Current Treatment Options in Cardiovascular Medicine·Jeroen DauwWilfried Mullens
Jun 21, 2019·Circulation. Arrhythmia and Electrophysiology·Albert K FeenyMina K Chung
Feb 26, 2021·Journal of the American Heart Association·Niraj VarmaUNKNOWN CHAMPION Investigator Group
May 10, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Niraj VarmaWojciech Zareba
May 27, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Wilfried MullensChristophe Leclercq
Jul 2, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Niraj VarmaMichael Gold
Jul 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Baldeep Singh SidhuChristopher A Rinaldi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Related Papers

© 2022 Meta ULC. All rights reserved