Abstract
Data regarding cardiac resynchronization therapy (CRT) in patients with multiple comorbidities are limited. This study evaluated the association of multiple comorbidities with the benefits of CRT over implantable cardioverter-defibrillator (ICD) alone. We examined 1,214 MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) study patients with left bundle branch block (LBBB) and 0, 1, 2, or ≥3 comorbidities, including renal dysfunction, hypertension (HTN), diabetes, coronary artery disease, history of atrial arrhythmias, history of ventricular arrhythmias, current smoking, and cerebrovascular accident. In an adjusted analysis, we analyzed risk of heart failure (HF) events or death by comorbidity group in all patients and in patients with CRT with defibrillator (CRT-D) versus ICD. Then we examined percent change in left ventricular (LV) end-diastolic volume, LV end-systolic volume, LV ejection fraction, left atrial volume, and LV dyssynchrony at 1-year in CRT-D patients by comorbidity group. There was an inverse relationship between comorbidity burden and improvements in LV end-systolic volume, LV end-diastolic volume, left ventricular ejection fraction, left atrial volume, and ...Continue Reading
Citations
Mar 7, 2018·Current Treatment Options in Cardiovascular Medicine·Neal A Chatterjee, E Kevin Heist
Nov 15, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Timothy F Christian
Feb 20, 2018·ESC Heart Failure·Felix HohendannerFrank R Heinzel
Mar 24, 2018·Pacing and Clinical Electrophysiology : PACE·John M FontaineLilian E Ahiable
Jan 13, 2018·Circulation. Arrhythmia and Electrophysiology·Matthew M KalscheurC David Page
Feb 20, 2018·Current Heart Failure Reports·Jad Al DanafAmin Yehya
Dec 28, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francisco LeyvaTian Qiu
Jan 1, 2020·Journal of the American Heart Association·Eyal NofRoy Beinart
Jan 11, 2020·European Heart Journal·Márton TokodiAnnamária Kosztin
Sep 19, 2020·ESC Heart Failure·Jiří KvasničkaEva Čermáková
Jan 5, 2018·European Heart Journal·Lars H LundFrank Ruschitzka
Jul 26, 2019·Current Treatment Options in Cardiovascular Medicine·Jeroen DauwWilfried Mullens
Jun 21, 2019·Circulation. Arrhythmia and Electrophysiology·Albert K FeenyMina K Chung
Nov 3, 2020·European Journal of Heart Failure·Wilfried MullensChristophe Leclercq
Feb 26, 2021·Journal of the American Heart Association·Niraj VarmaUNKNOWN CHAMPION Investigator Group
May 10, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Niraj VarmaWojciech Zareba
May 27, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Wilfried MullensChristophe Leclercq
Jul 2, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Niraj VarmaMichael Gold
Jul 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Baldeep Singh SidhuChristopher A Rinaldi
Aug 14, 2021·Journal of Arrhythmia·Hiro YamasakiKazutaka Aonuma
Sep 10, 2021·Heart and Vessels·Takahiko NagaseMitsuaki Isobe