PMID: 9634429Jun 20, 1998Paper

Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients

Annals of Internal Medicine
R W ShaferT C Merigan

Abstract

Drug resistance of HIV-1 is an obstacle to the long-term efficacy of antiretroviral therapy. To characterize reverse transcriptase and protease genes of multidrug-resistant HIV-1 isolates. Descriptive case series. Academic medical center. Four consecutive patients with HIV-1 infection were selected because they had previously received many antiretroviral drugs and had not achieved plasma HIV-1 RNA suppression despite treatment with several three-drug combinations. Reverse transcriptase sequencing, protease sequencing, and drug susceptibility testing of HIV-1. Isolates of HIV-1 from the four patients shared seven protease mutations and eight reverse transcriptase mutations. These mutations were present in biological clones and at three time points in three of the patients. Susceptibility testing showed high-level resistance (30-fold to >100-fold) to zidovudine, lamivudine, saquinavir, indinavir, and nelfinavir and lower-level resistance (3-fold to 5-fold) to didanosine, zalcitabine, and stavudine. Simultaneous resistance to almost all available antiretroviral drugs may occur in HIV-1. The concordance and persistence of mutations in drug-resistant HIV-1 isolates suggest that some combinations of reverse transcriptase and protease...Continue Reading

Citations

Nov 30, 2000·Current Infectious Disease Reports·G J Hanna, R T D'Aquila
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·Rituraj Purohit, Rao Sethumadhavan
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·David A WheelerMiklos Salgo
Jan 29, 2000·Journal of Immunological Methods·W A MarascoA Winkler
Mar 15, 2000·Journal of Virological Methods·M PirounakiL Ratner
Dec 22, 1999·International Journal of Immunopharmacology·R BowdenS Specter
May 25, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R W Shafer, D A Vuitton
Feb 6, 1999·Bioorganic & Medicinal Chemistry Letters·C T BakerR D Tung
Mar 20, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·B ZöllnerR Laufs
Jun 22, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M Arens
Jul 20, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Amilcar TanuriPedro N Chequer
Feb 26, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Palanee AmmaranondAnthony D Kelleher
Aug 3, 1999·European Journal of Biochemistry·B MahalingamI T Weber
Jul 31, 1998·The New England Journal of Medicine·O J Cohen, A S Fauci
Jun 22, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P R Harrigan, H C Côté
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D DionisioM Polidori
May 22, 2001·AIDS Patient Care and STDs·V SorianoJ González-Lahoz
Mar 4, 2003·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Perry N HalkitisJeffrey T Parsons
Dec 10, 1998·Nucleic Acids Research·R W ShaferB Chan
Dec 11, 1999·Nucleic Acids Research·R W ShaferM J Gonzales
Jan 26, 2008·HIV Medicine·S LouvelUNKNOWN Swiss HIV Cohort Study

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.