Multiple copies of RUNX1: description of 14 new patients, follow-up, and a review of the literature

Cancer Genetics and Cytogenetics
Patricia Pérez-VeraAlessandra Carnevale

Abstract

RUNX1 over-representation is present in children with acute lymphoblastic leukemia. Although these cases have been related with poor outcome, not all reports describe patient follow-up. To understand its associated clinical features and prognosis, we report on 14 children with ALL and RUNX1 over-representation with laboratory data and outcomes compared to previous reports. Eighty-six children with RUNX1 over-representation have been described, including the 14 patients of this study. Most of them are between 6 and 15 years of age, have low leukocyte counts, pre-B immunophenotype, and three to eight RUNX1 copies. Of the 69 patients with follow-up data, 21 of them relapsed or died, suggesting that RUNX1 over-representation is associated to a poor outcome.

References

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Citations

Feb 16, 2010·Expert Reviews in Molecular Medicine·Constanze Bonifer, David T Bowen
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kaaren K ReichardSheldon Robinett
Jul 18, 2012·Genes & Development·Benjamin G Neel, Nancy A Speck
Jan 6, 2010·Advances in Hematology·Abir GmidèneAli Saad
Jul 4, 2012·Leukemia Research·Oreth Montero-RuízPatricia Pérez-Vera
Jan 27, 2009·Cancer Genetics and Cytogenetics·Seyed A MoosaviAdewale Adeyinka
Mar 7, 2017·Archives of Medical Research·Dulce María López-SánchezAngélica Rangel-López

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