Multiple dose pharmacokinetics of an oral solution of itraconazole in patients receiving chemotherapy for acute myeloid leukaemia

The Journal of Antimicrobial Chemotherapy
A G PrenticeD A Oliver

Abstract

The multiple dose pharmacokinetics of a solution of itraconazole given orally were measured in an open study of 20 patients undergoing remission induction chemotherapy for acute myeloid leukaemia. Patients were given itraconazole 5 mg/kg od, 2.5 mg/kg bd, 2.5 mg/kg od or 1.25 mg/kg bd. The mean daily dose of itraconazole was 407 mg for patients receiving 5 mg/kg/day and 148 mg in patients receiving 2.5 mg/kg/day. Mean concentrations of 493 and 495 micrograms/L were achieved on day 8 in patients who received 5 mg/kg/d od or 2.5 mg/kg bd itraconazole respectively. However, mean concentrations were significantly lower for those who received 2.5 mg/kg od itraconazole being 110 micrograms/L on day 8. Mean areas under the serum-concentration time curves were also markedly higher in patients receiving 5 mg/kg/day than in those receiving 2.5 mg/kg/day itraconazole and were 22,382 and 5615 micrograms.h/L on day 15 respectively. These findings suggest that the serum concentrations attained with an oral solution of 5 mg/kg itraconazole either once daily or in two divided doses are suitable for antifungal prophylaxis in patients receiving chemotherapy for acute myeloid leukaemia.

Citations

Nov 28, 2001·Current Infectious Disease Reports·David W. WarnockBrent A. Lasker
Apr 11, 2001·Current Oncology Reports·R E Segal, G Y Minamoto
Nov 20, 1998·The Journal of Infection·H F KennedyJ R Michie
Aug 5, 2000·International Journal of Antimicrobial Agents·S AsciogluJ F Meis
Oct 29, 2000·International Journal of Antimicrobial Agents·J P Donnelly
Mar 23, 1999·British Journal of Haematology·E C WilliamsonD I Marks
Sep 6, 2000·British Journal of Haematology·H G PrenticeA G Prentice
Jun 26, 2001·Journal of Clinical Pharmacy and Therapeutics·L WillemsK de Beule
Apr 9, 1999·Medicine·D L Paterson, N Singh
Jan 11, 2007·Antimicrobial Agents and Chemotherapy·Gopal KrishnaLisa Pedicone
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·C SchmittJ C Levron
Nov 24, 1999·Journal of Clinical Pathology·P C HuijgensA R Jonkhoff
May 20, 1999·Pharmacotherapy·D A Stevens
Feb 24, 2001·Drugs·J F Meis, P E Verweij
Feb 24, 2001·Drugs·K De Beule, J Van Gestel
Mar 7, 2014·Clinical Pharmacokinetics·Chris StockmannCatherine M T Sherwin
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J A Maertens
May 3, 2001·Blood Reviews·A G Prentice, P Donnelly
Oct 13, 2007·Expert Opinion on Pharmacotherapy·Christine C ChiouAndreas H Groll
Jan 21, 2014·Clinical Therapeutics·Panayiotis D ZiakasEleftherios Mylonakis
Apr 26, 2016·Expert Opinion on Drug Metabolism & Toxicology·Jennifer L Goldman, Susan M Abdel-Rahman
Feb 6, 2002·European Journal of Cancer Care·J MaertensM Boogaerts
Oct 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eyal RobenshtokMical Paul
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Axel GlasmacherIngo G H Schmidt-Wolf
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mauricette Michallet, James I Ito
Jun 15, 1999·Journal of the American Academy of Dermatology·R J Hay
May 21, 2005·Therapeutic Drug Monitoring·Susan S BuchkowskyMary H H Ensom
Jul 27, 2017·Clinical and Experimental Pharmacology & Physiology·Sarah AllegraAntonio D'Avolio
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·R Quilitz
Dec 2, 2004·Dermatologic Therapy·Jashin J WuStephen K Tyring

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.