PMID: 15333267Aug 31, 2004Paper

Multiple drug resistance: a threat for tuberculosis control

Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Ernesto Montoro Cardoso

Abstract

Drug-resistant tuberculosis (TB) was reported soon after the introduction of streptomycin, although it did not receive major attention until recently. It was not considered a major issue in the industrialized world until outbreaks of multidrug-resistant TB (MDR-TB) were reported among HIV infected people. Administration of standard short-course chemotherapy (SSCC) with first-line drugs under directly observed therapy (DOT) is the cornerstone of modern TB control. Unfortunately, data available on the treatment outcome of MDR-TB cases under routine programmatic conditions suggest that patients with MDR-TB respond poorly to SSCC with first-line drugs. Since 1994, the World Health Organization and the International Union Against Tuberculosis and Lung Disease (IU-ATLD) have conducted anti-TB drug resistance surveys through a network of subregional laboratories and researchers. Drug resistance was present in almost all settings surveyed, and prevalence varied widely across regions. High prevalence of MDR-TB is widespread in the Russian Federation and areas of the former Soviet Union (Estonia, Kazakhstan, Latvia, and Lithuania) as well as Israel, Liaoning and Henan Provinces in China, and Ecuador. The Global Project has surveyed areas...Continue Reading

Citations

May 9, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Man Chin ChungLorena Blau
Sep 5, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Souba DiandéAlfred S Traoré
Aug 19, 2008·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yi HuBiao Xu
Mar 21, 2006·Chemical Research in Toxicology·Lian Qian, Paul R Ortiz de Montellano

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