PMID: 6967867Apr 1, 1980Paper

Multiple effects induced by unstable mutation in Streptomyces lavendulae

The Journal of Antibiotics
M M Nakano, H Ogawara

Abstract

Arg mutants, isolated from Streptomyces lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: (1) repression of beta-lactamase production, (2) inhibition of aerial mycelium formation, (3) development of acid pH, (4) low saturation density of growth in liquid culture, (5) a decrease in antibiotic production, (6) an increase in sensitivity to benzylpenicillin and (7) a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.

Citations

Jan 1, 1984·Molecular & General Genetics : MGG·S KlausF Walter
Jan 1, 1982·Molecular & General Genetics : MGG·S KlausU Taubeneck
Oct 1, 1987·Journal of Bacteriology·P Dyson, H Schrempf

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