PMID: 3301663Aug 1, 1987

Multiple effects of calcium entry blockers on renal function in hypertension

J C RomeroJ L Rodicio


Characterization of the renal effects of calcium entry blockers has not been easy because the inhibition of Ca2+ cellular influx alters several regulatory functions. The ability of calcium blockers to dilate renal vasculature and to increase glomerular filtration rate is largely determined by the preexisting vascular tone. However, the increments in sodium excretion could occur without alterations in renal hemodynamics. Calcium blockers could increase sodium excretion by inducing a redistribution of renal blood flow toward juxtamedullary nephrons, by inhibiting tubuloglomerular feedback responses, or by a direct action on the tubular transport of sodium. These effects are poorly understood at present. In vitro studies show that the blockade of calcium entry enhances renin secretion and decreases prostaglandin synthesis. This dissociation has not been found during long-term administration, which has been proved to be effective for the treatment of essential hypertension with normal maintenance of renal function. In this respect, there are reports indicating that calcium blockers are particularly effective in a subgroup of patients with essential hypertension who exhibit subtle but detectable alterations in calcium metabolism. Fu...Continue Reading


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Related Concepts

Calcium [EPC]
Kidney Function Tests
Blood Vessel
Thyroid Hormone Plasma Membrane Transport Defect
Essential Hypertension
Process of Secretion
Glomerular Filtration Rate
Body Excretions

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