Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function

Kidney International
Bettina Haslinger-Löffler

Abstract

The paper by Sharyo et al. shows that statins reduce the severity in a model of renal-ischemia reperfusion injury and raises the therapeutic possibility of using statins as pharmacological intervention against acute kidney injury. This, together with previous studies, indicates that statins exert a wide spectrum of anti-inflammatory, immunomodulatory, and protective effects besides their lipid-lowering function.

References

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Citations

Aug 21, 2013·Pharmacoepidemiology and Drug Safety·J Bradley LaytonAbhijit V Kshirsagar
Oct 6, 2011·Life Sciences·Yen-Hwang ChuangChun-Hsiung Huang
Jan 27, 2015·Current Cardiology Reports·Saurav ChatterjeeDharam J Kumbhani
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed M A Hussein, Mohamed K Mahfouz
Jul 8, 2016·Nature Reviews. Cardiology·Joe W E Moss, Dipak P Ramji
Mar 12, 2015·The Cochrane Database of Systematic Reviews·Michelle LewickiAntoine G Schneider
Jun 18, 2010·American Journal of Physiology. Renal Physiology·Sara GiuntiKarin A Jandeleit-Dahm
Mar 17, 2020·Future Medicinal Chemistry·Yee-Hung Chan, Dipak P Ramji

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