Multiple endocrine neoplasia type 1 in patients with recognized pituitary tumours of different types

Clinical Endocrinology
S CorbettaA Spada

Abstract

We have investigated the prevalence of MEN 1 in patients with recognized pituitary adenomas. Since hyperparathyroidism is present in nearly 95-100% of patients with MEN 1 and frequently is the first condition to be identified, the study was limited to the identification of patients with hyperparathyroidism while the screening for gastroenteropancreatic (GEP) lesions was carried out in patients with both pituitary and parathyroid lesions. Serum total and ionized calcium, phosphate and intact PTH 1-84 (EASIA) were measured in 166 patients (68 with non-functioning pituitary adenoma, 42 with prolactinoma, 35 with GH-secreting adenoma, 17-with ACTH-screening adenoma, 1 with TSH-secreting adenoma, 1 with FSH-secreting adenoma and 2 with an only alpha-subunit secreting adenoma) referred to our clinic from 1990 to 1996. Plasma gastrin, somatostatin, pancreatic polypeptide and vasoactive intestinal peptide were measured by RIA in patients with hyperparathyroidism. Eight of 166 patients (4.8%) were found to have primary hyperparathyroidism and among these 2 also had a gastrinoma while there was no evidence of other GEP tumours. Considering the tumour type, 6 had prolactinoma (14.3%), 1 GH-secreting adenoma (2.8%) and 1 non-functioning ad...Continue Reading

Associated Clinical Trials

Citations

Oct 18, 2000·Endocrinology and Metabolism Clinics of North America·R V Thakker
Jun 10, 2000·European Journal of Clinical Investigation·J F RoijersC J Lips
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·T J TaylorK D Burma
Feb 24, 2001·Australian and New Zealand Journal of Medicine·D L LearoydB G Robinson
Feb 15, 2011·International Journal of Endocrinology·Grzegorz PiechaAndrzej Więcek
Mar 14, 2013·World Journal of Gastroenterology : WJG·Ying-Ying LuXing-Peng Wang
Dec 17, 2014·Current Problems in Cancer·Rebecca Nagy
Oct 19, 2010·Cancer Genetics and Cytogenetics·Madson Q Almeida, Constantine A Stratakis
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Rajesh V Thakker
Feb 6, 2008·European Journal of Internal Medicine·Grzegorz PiechaAndrzej Wiecek
Jul 26, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·R N Clayton
Dec 3, 2014·Neurologia Medico-chirurgica·Hidenori Fukuoka, Yutaka Takahashi
Feb 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Cesar Luiz BoguszewskiTeresa Cristina Santos Cavalcanti
Feb 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Helena Campos FabbriGil Guerra-Júnior
Feb 7, 2018·Pituitary·Maria Chiara Zatelli
Dec 14, 1999·Pathology International·T FujiiM Fukayama
Jun 22, 2018·Clinical Endocrinology·Angeliki MakriMaya Lodish
Jun 2, 2017·European Journal of Endocrinology·Axel Tjörnstrand, Helena Filipsson Nyström
Jul 1, 2009·Nature Reviews. Endocrinology·Marianne S ElstonBruce G Robinson
Aug 24, 2004·Oncogene·Rebecca NagyCharis Eng
Apr 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Lisa B NachtigallRajesh V Thakker
Jan 15, 2005·Journal of Endocrinological Investigation·G TamagnoN Sicolo
Aug 1, 2012·The Cancer Journal·Robert Pilarski, Rebecca Nagy
Mar 1, 2011·Expert Review of Endocrinology & Metabolism·Marie-Lise Jaffrain-ReaAlbert Beckers
Jun 25, 2020·Journal of Human Reproductive Sciences·Raiz Ahmad MisgarMir Iftikhar Bashir
Jul 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan D WassermanJoshua D Schiffman
Jul 23, 1999·The Medical Journal of Australia·J R Burgess
Jul 23, 1999·The Medical Journal of Australia·D L Learoyd, B G Robinson
Apr 4, 2021·Journal of Clinical Medicine·Anna Bogusławska, Márta Korbonits

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.