PMID: 9167955Jan 1, 1997Paper

Multiple endocrine neoplasia type 2: management of patients and subjects at risk. French Study Group on Calcitonin-Secreting Tumors (GETC)

Hormone Research
B Conte-DevolxE Modigliani

Abstract

Multiple endocrine neoplasia type 2 (MEN-2) is an inherited multiglandular disease with age-related penetrance and variable expression. The prognosis of MEN-2 is linked to the carcinological evolution of medullary thyroid cancer (MTC), which depends mainly on the stage of discovery, and to the incidents related to pheochromocytomas. The emphasizes the need for early diagnosis and management of MEN-2. Since 1993, mutations evidenced on the protooncogene RET have allowed subjects at risk to be identified, thus leading to a three-step management of these patients. (1) For all the potentially affected members of a MEN-2 family, screening by molecular genetics of the ret gene enables one to identify the subjects at risk who bear the mutation. When no mutation is observed, a linkage analysis study may be proposed. (2) In the subjects at risk, early screening for the various types of endocrine lesions may then start in childhood and be performed using specific biological markers of MTC, pheochromocytoma and primary hyperparathyroidism, and particularly, basal and pentagastrin-stimulated calcitonin measurement, which is known to be the most sensitive marker for the monitoring of MTC. (3) This step of biological investigations enables t...Continue Reading

Citations

Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·M EngelbachJ Beyer
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M WienchB Jarzab
Sep 29, 2001·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·E Giarelli
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Maria A KouvarakiDouglas B Evans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Related Papers

La Presse médicale
B Conte-DevolxGroupe d'Etude des Tumeurs à Calcitonine
Arquivos brasileiros de endocrinologia e metabologia
Marcelo A C G dos SantosSergio Pereira de Almeida Toledo
Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism
E ModiglianiP Niccoli-Sire
© 2021 Meta ULC. All rights reserved