PMID: 11980085Nov 1, 1995Paper

Multiple endocrine neoplasia type two B. A case report with light and electron microscopic and immunohistochemical correlation

Australian and New Zealand Journal of Ophthalmology
L K KohMarijan Filipic

Abstract

To describe a case of multiple endocrine neoplasia type two B (MEN IIB) where ocular and systemic clinicopathological findings are correlated, in association with light and electron microscopic and immunohistochemical findings. A 23-year-old man presented with mucosal neuromas of the lips, tongue and eyelids, a Marfanoid habitus and prominent corneal nerves. These findings led to the diagnosis of multiple endocrine neoplasia type two B. The patient subsequently developed phaeochromocytoma and metastatic medullary thyroid carcinoma (MTC) which led to his demise. Correlation of light and electron microscopic and immunohistochemical findings with the systemic and ocular findings is presented to emphasise the aggressiveness of MTC in MEN IIB. Clinicopathological correlation was obtained by examining the eyes post mortem. Three new findings in MEN IIB have been established by this study. The enlarged corneal nerves can now be regarded as ganglioneuromas. Medullary thyroid carcinoma metastases were found in the choroid. Light and electron microscopic examination of the eye showed ganglioneuromas of the nerves in the limbus, trabecular meshwork, uveal tract and posterior ciliary nerves; this finding may account for the glaucoma occasi...Continue Reading

References

Feb 1, 1979·The Surgical Clinics of North America·J A NortonS A Wells
Nov 2, 1978·The New England Journal of Medicine·K GrazeS Reichlin
Jun 1, 1992·Archives of Internal Medicine·H F VasenC J Lips
May 1, 1990·Australian and New Zealand Journal of Ophthalmology·P L MackenG M Whitehouse
Dec 1, 1990·Journal of Surgical Oncology·J A Van ZylD J Van Velden
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E AineP Miettinen
Jan 1, 1981·American Journal of Ophthalmology·F C Riley, D M Robertson
Feb 1, 1981·American Journal of Ophthalmology·B SpectorS A Wells

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Citations

Oct 1, 2003·American Journal of Ophthalmology·Ian C Francis, Marijan Filipic
Jan 25, 2007·Acta Ophthalmologica Scandinavica·Jens Henrik Søndergaard Pedersen, Ove Schaffalitzky De Muckadell
Sep 23, 2008·Ophthalmic Plastic and Reconstructive Surgery·Katherine MasselosIan C Francis
Sep 22, 2012·Journal of Agromedicine·Karen Canton, Warwick Williams
Mar 19, 2002·Ophthalmic Plastic and Reconstructive Surgery·Ian C Francis, Marijan Filipic
Oct 5, 2012·Ophthalmic Plastic and Reconstructive Surgery·Sun Hee Kang, Keun Hae Kim
May 9, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jessica E GosnellQuan-Yang Duh

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