PMID: 1913529Oct 15, 1991Paper

Multiple endocrine syndrome type IIb in early childhood

N A SamaanR A Lewis


A 3-week-old girl who was born with club feet had signs of failure to thrive. On physical examination the child appeared normal; she had no abnormalities in the mucous membranes of the mouth, the eyelids, or in the neck, and her other systems, including heart, chest, abdomen, and neurologic systems, were clinically normal. Radiologically, the gastrointestinal tract was normal, but rectal biopsy showed neuromas. Her serum calcitonin level was measured both at basal and after pentagastrin stimulation at 5 weeks of age and found to be high, but whether it was consistent with the normal level at this early age or was caused by medullary thyroid carcinoma was not clear. At 3 months, the corneal nerves of both eyes were examined and showed considerable thickening, and multiple endocrine syndrome type IIb was suspected. The serum calcitonin level at 8 and 14 months was increased. A total thyroidectomy was done, and C-cell nodular hyperplasia and adenomatosis was found in the isthmus. The postoperative serum calcitonin level decreased to low normal and did not increase after pentagastrin stimulation. To the authors' knowledge, this case represents the youngest patient diagnosed with multiple endocrine syndrome type IIb in the absence o...Continue Reading


Nov 2, 1978·The New England Journal of Medicine·K GrazeS Reichlin
Aug 1, 1977·The Surgical Clinics of North America·G W SizemoreH Heath
Mar 1, 1975·American Journal of Obstetrics and Gynecology·N A SamaanM E Adam-Mayne
Jul 1, 1989·Archives of Surgery·R L TelanderC S Grant
Feb 1, 1983·The Journal of Pediatrics·B A Jones, J C Sisson
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·M R StjernholmL J Deftos

❮ Previous
Next ❯


Jun 22, 2005·Current Treatment Options in Oncology·Amber Traugott, Jeffrey F Moley
Jul 1, 1995·Baillière's Clinical Endocrinology and Metabolism·G J CoteR F Gagel
May 18, 2001·Surgical Oncology·N C Lee, J A Norton
Aug 30, 2003·Surgical Oncology·Michael A Skinner
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
May 2, 2012·Journal of Pediatric Hematology/oncology·Louis Rapkin, Farzana D Pashankar
Sep 8, 2010·Current Problems in Surgery·Ismail JatoiMichael A Choti
Feb 19, 2005·Journal of Surgical Oncology·Frank J Quayle, Jeffrey F Moley
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Jan 1, 1996·Journal of Pediatric Surgery·M A SkinnerS A Wells
May 26, 2004·Clinics in Laboratory Medicine·Nicole Massoll, Ernest L Mazzaferri
Jul 27, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·R Mihai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.