Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

International Journal of Dermatology
Tsung-Ju Lee, Yu-Hung Wu

Abstract

Epidermolytic acanthoma (EA) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple EAs) are rarely reported. We retrospectively identified patients diagnosed with multiple EAs between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. We also evaluated the association of multiple EAs with human papillomavirus (HPV) infection. In total, eight patients (average age 51 years; 3 : 1 male predominance) with multiple EAs were found. All patients had lesions on the genitocrural area. The two most common clinical diagnoses were condyloma (5/8) and soft fibroma (3/8), which were predominantly skin-colored (5/8) or whitish (2/8). The lesions were less than 1 cm in diameter, and most (6/8) appeared to have a smooth surface. No molecular evidence suggesting HPV infection was found. Immunohistochemical staining showed low mitotic activity. The lesions were removed in one of two patients via cryotherapy, and one patient was treated with electrocauterization. The other five patients were followed without treatment. The genital area was the most common location for multiple EAs, which was commonly misdiagnosed clinically as condyloma. Patie...Continue Reading

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Citations

Jan 22, 2019·Journal of Cutaneous Pathology·Simon F RoyJennifer M McNiff
Sep 12, 2018·Archives of Pathology & Laboratory Medicine·May P Chan
Feb 12, 2020·Journal of Cutaneous Pathology·Shayan CheraghlouKeith A Choate
Oct 8, 2020·World Journal of Clinical Cases·Ariana S GinsbergJoseph P Terlizzi
Apr 30, 2021·Annals of Dermatology·Hyun Jeong ByunDong-Youn Lee

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