Multiple epigenetic biomarkers for evaluation of students' academic performance

Genes, Brain, and Behavior
Li-Ching LeeChun-Yen Chang

Abstract

Several reports have shown that methyl CpG-binding protein 2 (MeCP2), brain-derived neurotrophic factor (BDNF), phospho-cAMP response element-binding protein (p-CREB) and microRNAs may be important in regulating academic performance because of their roles in neuropsychiatry and cognitive diseases. The first goal of this study was to explore the associations among MeCP2, BDNF, CREB and academic performance. This study also examined the pathway responsible for the effects of MeCP2, BDNF, p-CREB and microRNAs on academic performance. Scores from the basic competency test, an annual national competitive entrance examination, were used to evaluate academic performance. Subjects' plasma RNA was extracted and analyzed. This study determined that participants in the higher academic performance group had a significant difference in MECP2 mRNA expression compared with the lower academic performance group. We then used neuronal human derived neuroblastoma cell line (SH-SY5Y) cells with inducible MeCP2 expression from a second copy of the gene as a gain-of-function model and found that MeCP2 overexpression positively affected p-CREB and BDNF expression initially. After negative feedback, the p-CREB and BDNF levels subsequently decreased. I...Continue Reading

References

Nov 9, 2007·Neuron·Maria Chahrour, Huda Y Zoghbi
Nov 13, 2007·Nature Neuroscience·Matthew E KleinRichard H Goodman
Nov 6, 2009·Nature Reviews. Neuroscience·Gerhard Schratt
Apr 29, 2010·American Journal of Medical Genetics. Part a·Melissa B RamockiSarika U Peters
Feb 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vijay Chandrasekar, Jean-Luc Dreyer
Apr 29, 2011·Neurobiology of Learning and Memory·Timothy W BredyJohn S Mattick
Jul 5, 2011·Annual Review of Cell and Developmental Biology·Jacky GuyAdrian Bird
Apr 25, 2012·PloS One·Li-Ching LeeJung-Yaw Lin
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaofen ZhongQiang Chang
Sep 25, 2012·Aging·Kira S SheinermanSamuil R Umansky
Sep 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa P BlackmanGina G Turrigiano
Apr 17, 2013·Neuropharmacology·Nina N Karpova
Jul 24, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jingwen LvZilong Qiu
Jan 7, 2014·Frontiers in Cellular Neuroscience·Simona MaciottaYvan Torrente
Mar 22, 2014·EMBO Molecular Medicine·Martesa TantraHannelore Ehrenreich
Aug 20, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ayla Aksoy-AkselGerhard Schratt
Oct 4, 2014·Neurochemistry International·Carol E VásquezGabrielle B Britton
Mar 31, 2015·Behavioural Brain Research·Julia Hernandez-RappSébastien S Hébert
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Lin ChenHuda Y Zoghbi
Jan 17, 2016·Learning & Memory·Katelin F HansenKarl Obrietan
May 21, 2016·Child and Adolescent Psychiatry and Mental Health·Chan-Woo YeomSoo-Young Bhang
Jul 16, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hyunjung OhEtienne Sibille
Jan 31, 2017·International Journal of Molecular Sciences·Gonzalo S Tejeda, Margarita Díaz-Guerra
Feb 28, 2017·Behavioural Brain Research·Ana Cristina R CamargosAna Cristina Rodrigues Lacerda
May 13, 2017·International Journal of Molecular Sciences·Koichi UegakiMasami Kojima
Jul 25, 2018·Journal of Molecular Neuroscience : MN·M R Beltran-VallsD Moliner-Urdiales

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Masatake KuritaNorimichi Nakahata
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Mehmet GencerRecai Türkoğlu
Progress in Neuro-psychopharmacology & Biological Psychiatry
Chan LiZhixian Mo
© 2022 Meta ULC. All rights reserved