Multiple equilibria of cations with metabolites in muscle bioenergetics

The American Journal of Physiology
Martin J Kushmerick

Abstract

The multiple ionic forms of metabolites were evaluated at 37 degrees C for four reactions important in muscle contraction and recovery: 1) ATPase, 2) creatine kinase, 3) the Lohmann reaction, and 4) the Lohmann reaction reversed by coupling to glycogenolysis and glycolysis. Solution of the system of equations defining the multiple equilibria of the proton and cation complexes gives the concentration of each ionic form and a value for the proton stoichiometry for each reaction. The proton stoichiometric coefficients are unique for each reaction and are a function of pH because of differential binding of Mg2+ and K+ to adenine nucleotides, phosphocreatine, and Pi and because of different acidic dissociation constants for the metabolites. These results show the need to consider the binding of K+ in addition to the previously documented effects of Mg2+ in the cytoplasmic milieu. Commercially available software was used to show that related problems can be calculated readily on personal computers in applications similar to those described here.

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Citations

Jul 18, 2000·American Journal of Physiology. Cell Physiology·P Vicini, M J Kushmerick
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bruce M DamonM Joan Dawson
Mar 4, 2003·Journal of Applied Physiology·David BendahanPatrick J Cozzone
Aug 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Graham Kemp
Nov 30, 2005·The Journal of Biological Chemistry·Bernard Korzeniewski
Dec 24, 2005·Muscle & Nerve·Michael I TrenellCampbell H Thompson
Sep 2, 2006·The Journal of Physiology·Ian R LanzaJane A Kent-Braun
Apr 21, 2007·The Journal of Physiology·Graham Kemp
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin MeyerspeerEwald Moser
Feb 2, 2008·The Journal of Physiology·Sharon A JubriasMartin J Kushmerick
Jul 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Charlotte BrønsAllan Vaag
Jan 8, 2011·Journal of Applied Physiology·Kalyan C Vinnakota, Martin J Kushmerick
Feb 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gwenael LayecDavid Bendahan
Aug 3, 2017·Medicine and Science in Sports and Exercise·Ryan M BroxtermanRussell S Richardson
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C Hsu, M J Dawson
Nov 16, 2002·Journal of Applied Physiology·M RousselD Bendahan
Mar 26, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alex C Hsu, M Joan Dawson
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Gregory J CrowtherKevin E Conley
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Jul 6, 2000·The Journal of Physiology·K E ConleyP C Esselman
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Sep 30, 2003·The Journal of Physiology·Sharon A JubriasKevin E Conley
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Mar 3, 2007·American Journal of Physiology. Cell Physiology·Anushka MichailovaAndrew McCulloch

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