Multiple facial basal cell carcinomas in xeroderma pigmentosum treated with topical imiquimod 5% cream

Dermatologic Therapy
Jian-Qiang YangJian-You Wang

Abstract

Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by solar sensitivity, photophobia, early onset of freckling, and solar-induced cutaneous neoplastic changes. Management of patients with XP is a therapeutic challenge as they usually develop multiple cutaneous malignancies, making surgical therapy difficult, and continue to form skin malignancies at a high rate. We describe a 30-year-old Chinese man with XP who had been previously treated with excision and dermatoplasty. Upon recurrence of multiple superficial, ulcerative, and pigmented lesions, imiquimod 5% cream was recommended for 4 months. His multiple facial lesions demonstrated an excellent response to topical imiquimod 5% cream with minor side effects. This favorable response indicates that topical application of imiquimod 5% cream is an effective means of treating multiple basal cell carcinomas in XP.

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Citations

Feb 18, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Mareike AlterRalf Gutzmer
Aug 20, 2015·Indian Journal of Pharmacology·Aditya Kumar Bubna
Jan 30, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·I LatourA Torrelo
Dec 1, 2018·British Journal of Pharmacology·Rosella AbetiPaola Giunti
Mar 4, 2017·Case Reports in Medicine·Esteban Uribe-BojaniniAlicia María Cock-Rada
Jul 1, 2018·American Journal of Clinical Dermatology·Amanda F NahhasHenry W Lim
Dec 18, 2020·Dermatologic Therapy·Qiaochu ZhouWei Wang
Mar 27, 2021·Indian Journal of Dermatology, Venereology and Leprology·Fernando Antônio Gomes de AndradeLydia Masako Ferreira

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