PMID: 7539579Jun 1, 1995Paper

Multiple false reactions in viral antibody screening assays after influenza vaccination

American Journal of Epidemiology
L SimonsenL B Schonberger

Abstract

In December 1991, US blood centers reported an unusual increase in donations that tested falsely reactive for antibodies to two or more (multiple false positive) of the following viruses: human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotrophic virus type I (HTLV-I), and hepatitis C virus. Many of these donations were from people who had recently received the 1991-1992 influenza vaccine, raising the possibility that this vaccine had somehow specifically caused the problem of multiple false reactivity. A case-control study of 101 affected donors and 191 matched controls found that recent receipt of any brand of influenza vaccine was significantly associated with testing multiple false positive (p < 0.05), as was a history of recent acute illness (p < 0.05) and of allergies (p < 0.05). Surveillance for monthly rates of multiple reactive donations from May 1990 through December 1992 linked the seasonal cluster of multiple false-positive donations to the use of viral screening test kits thought to react nonspecifically to donor immunoglobulin M. There was no similar increase in multiple false-positive donations during the 1992-1993 influenza vaccination season after the HIV-1 and hepatitis C virus tests were replaced...Continue Reading

Citations

Feb 1, 2003·Transfusion·Usha K SharmaUNKNOWN Retrovirus Epidemiology Donor Study
Mar 31, 2006·The New England Journal of Medicine·Christian P EricksonJeffrey D Klausner
Sep 28, 2006·Transfusion·Kumar SrinivasanIndira Hewlett
Sep 30, 2010·Clinical Chemistry·Vinay S MahajanPetr Jarolim
Jun 27, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Elise M BeltramiDenise M Cardo
Jan 11, 2014·Expert Review of Anti-infective Therapy·Derryck KlarkowskiKasha P Singh
May 31, 2003·International Journal of Hematology·Shih Chien Lu, Bai Hsiun Chen
Sep 10, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Carolina de Alcantara ManeschyCarlos Eduardo de Melo Amaral

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