Multiple food hypersensitivity as a cause of refractory chronic constipation in adults

Scandinavian Journal of Gastroenterology
Antonio CarroccioMaurizio R Averna

Abstract

Chronic constipation that is unresponsive to laxative treatment is a severe illness, but children unresponsive to laxatives have been successfully treated with an elimination diet. We report the first cases of refractory chronic constipation caused by food hypersensitivity in adults. Four patients with refractory constipation who were unresponsive to high doses of laxatives were put on an oligo-antigenic diet and underwent successive double-blind, placebo-controlled, food challenges (DBPFC). Routine laboratory tests, immunological assays, colonoscopy, esophago-gastroduodenoscopy and rectal and duodenal histology were performed. While on an elimination diet, bowel habits normalized in all patients and a DBPFC challenge triggered the reappearance of constipation. In comparison with another 13 patients with refractory constipation unresponsive to the elimination diet, observed over the same period, the patients with food-hypersensitivity-related constipation had the following characteristics: longer duration of illness (p < 0.03), lower body mass index (p < 0.03), higher frequency of self-reported food intolerance (p < 0.01), higher frequency of nocturnal abdominal pain and anal itching (p < 0.01). In patients with food hypersensi...Continue Reading

References

Jan 11, 1992·BMJ : British Medical Journal·R Jones, S Lydeard
Oct 1, 1991·Gastroenterology·N J TalleyL J Melton
Aug 1, 1989·Digestive Diseases and Sciences·J E EverhartL R White
Jan 1, 1989·Diseases of the Colon and Rectum·A Sonnenberg, T R Koch
Sep 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·N IyngkaranK L Lam
Jan 1, 1995·The Journal of Pediatrics·G IaconoA Notarbartolo
Aug 1, 1993·Scandinavian Journal of Gastroenterology·A CarroccioA Notarbartolo
May 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·G IaconoG Montalto
Mar 1, 1996·The Journal of Allergy and Clinical Immunology·G IaconoA Notarbartolo
Apr 1, 1996·The Journal of Pediatrics·F CavataioG Iacono
Mar 1, 1996·Gastroenterology Clinics of North America·G R Locke
Aug 28, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G IaconoA Carroccio
Oct 15, 1998·The New England Journal of Medicine·G IaconoA Carroccio
Mar 20, 1999·The New England Journal of Medicine·S DaherM B de Morais
Oct 19, 1999·European Journal of Gastroenterology & Hepatology·G OberhuberH Vogelsang
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A CarroccioG Iacono
Aug 9, 2001·Clinical Pediatrics·J A VanderhoofR J Young
Aug 20, 2003·Digestive Diseases and Sciences·Antonio CarroccioAlberto Notarbartolo
Apr 22, 2005·Scandinavian Journal of Gastroenterology·Antonio CarroccioGiuseppe Iacono

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Citations

Jan 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antonio CarroccioGaetana Di Fede
Mar 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Giuseppe IaconoAntonio Carroccio
Oct 25, 2006·Alimentary Pharmacology & Therapeutics·A Carroccio, G Iacono
Mar 21, 2012·Alimentary Pharmacology & Therapeutics·P MansuetoA Carroccio
Apr 4, 2015·Expert Review of Gastroenterology & Hepatology·Renée M Marchioni Beery, John W Birk
Apr 24, 2013·The American Journal of Gastroenterology·Chu K YaoSusan J Shepherd
Apr 17, 2013·The American Journal of Gastroenterology·Antonio CarroccioSebastiano Bonventre
Oct 21, 2006·Current Opinion in Gastroenterology·Simon Murch
Oct 31, 2013·The American Journal of Gastroenterology·Antonio CarroccioGiuseppe Iacono
Sep 30, 2017·Journal of Gastroenterology and Hepatology·Alex Yu Sen SohKok-Ann Gwee
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Antonio CarroccioGaetana Di Fede
Mar 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Riccardo Troncone, Valentina Discepolo
Dec 3, 2011·Journal of Pediatric Gastroenterology and Nutrition·Anna VossenkämperThomas T MacDonald

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