Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development

Developmental Cognitive Neuroscience
Daniel G McHail, T C Dumas

Abstract

Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the end of the third postnatal week. Emergence of spatial learning and memory at this developmental stage suggests possible involvement of metaplasticity in the final maturation of the hippocampus. Three distinct metaplastic phenomena are apparent. (1) As transmitter release probability increases with increasing age, presynaptic potentiation is reduced. (2) Alterations in the composition and channel conductance properties of AMPARs facilitate the induction of postsynaptic potentiation with increasing age. (3) Low frequency stimulation inhibits subsequent induction of potentiation in animals older but not younger than 3 weeks of age. Thus, many forms of plasticity expressed at SC-CA1 synapses are different in rats younger and older than 3 weeks of age, illustrating the complex orchestration of physiological modifications that underlie the maturation of hippocampal excitatory synaptic transmission. This review paper describes three late postnatal modifications to synaptic plasticity ...Continue Reading

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Citations

Jun 20, 2016·Neurogenetics·Nicola BliimMichael Janitz
Apr 10, 2018·Neurobiology of Learning and Memory·Alejandro Rivera-OlveraMartha L Escobar
Apr 27, 2021·Biochemical and Biophysical Research Communications·Alexander V Maltsev, Pavel M Balaban

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