Multiple functional nanoprobe for contrast-enhanced bimodal cellular imaging and targeted therapy

Analytical Chemistry
Hong-Min MengWeihong Tan

Abstract

Many one-photon fluorescence-based theranostic nanosystems have been developed for simultaneous therapeutic intervention/monitoring for various types of cancers. However, for early diagnosis of cancer, two-photon fluorescence microscopy (TPFM) can realize deep-tissue imaging with higher spatial resolution. In this study, we first report a multiple functional nanoprobe for contrast-enhanced bimodal cellular imaging and targeted therapy. Components of the nanoprobe include (1) two-photon dye-doped mesoporous silica nanoparticles (TPD-MSNs); (2) MnO2 nanosheets that act as a (i) gatekeeper for TPD-MSNs, (ii) quencher for TP fluorescence, and (iii) contrast agent for MRI; (3) cancer cell-targeting aptamers. Guided by aptamers, TPD-MSNs are rapidly internalized into the target cells. Next, intracellular glutathione reduces MnO2 to Mn(2+) ions, resulting in contrast-enhanced TP fluorescence and magnetic resonance signal for cellular imaging. Meanwhile, preloaded doxorubicin and Chlorin e6 are released for chemotherapy and photodynamic therapy, respectively, with a synergistic effect and significantly enhanced therapeutic efficacy.

References

Jan 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C BensonG M McKhann
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A R OseroffM L Yarmush
Mar 20, 2003·Journal of the American Chemical Society·Yoshitomo OmomoMamoru Watanabe
Nov 5, 2003·Nature Biotechnology·Warren R ZipfelWatt W Webb
Nov 22, 2005·Nature Methods·Fritjof Helmchen, Winfried Denk
Jul 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dihua ShangguanWeihong Tan
Mar 28, 2008·Journal of Proteome Research·Dihua ShangguanWeihong Tan
Nov 4, 2008·Journal of the American Chemical Society·Kazuya KaiJun Kawamata
Jan 11, 2011·Journal of the American Chemical Society·Chun-Ling ZhuXiao-Ru Wang
Apr 1, 2011·Journal of the American Chemical Society·Goutam MasantaBong Rae Cho
May 18, 2011·Journal of the American Chemical Society·Faheem MuhammadGuangshan Zhu
Aug 19, 2011·Accounts of Chemical Research·Ji Eun LeeTaeghwan Hyeon
Nov 24, 2011·Journal of the American Chemical Society·Renren DengXiaogang Liu
Dec 12, 2012·Accounts of Chemical Research·Carmen CollFélix Sancenón
Oct 2, 2013·Optics Letters·Ido KaminerMordechai Segev
Jun 1, 2014·Chemical Communications : Chem Comm·Na LiBo Tang
Jul 26, 2014·Journal of the American Chemical Society·Zilong ZhaoWeihong Tan

❮ Previous
Next ❯

Citations

Jan 26, 2017·Chemical Communications : Chem Comm·Leli ZengHui Chao
Aug 30, 2017·Chemical Society Reviews·Jia WenShiguo Sun
Jul 13, 2018·Chemistry : a European Journal·Lorena García-HeviaJuan Gallo
Jun 5, 2020·Chemical Communications : Chem Comm·Jia WenShiguo Sun
Nov 28, 2017·Chemistry : a European Journal·Manuel Bañobre-LópezJuan Gallo
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Aug 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei-Yu MuQiu-Yun Chen
Apr 8, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Juan ChenYuehe Lin
Nov 5, 2020·ACS Applied Materials & Interfaces·Meihua LinFan Xia
Apr 12, 2019·Chemical Reviews·Bowen YangJianlin Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.