Multiple functions of m6 A RNA methylation in cancer

Journal of Hematology & Oncology
Yutian PanYongqian Shu

Abstract

First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have been proposed as another layer of epigenetic regulation similar to DNA and histone modifications. m6A RNA methylation is involved in all stages in the life cycle of RNA, ranging from RNA processing, through nuclear export, translation modulation to RNA degradation, which suggests its potential of influencing a plurality of aspects of RNA metabolism. All of the recent studies have pointed to a complicated regulation network of m6A modification in different tissues, cell lines, and space-time models. m6A methylation has been found to have an impact on tumor initiation and progression through various mechanisms. Furthermore, m6A RNA methylation has provided new opportunities for early stage diagnosis and treatment of cancers.Herein, we review the chemical basis of m6A RNA methylation, its multiple functions and potential significance in cancer.

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Methods Mentioned

BETA
dot-blot
MeRIP-seq
immunoprecipitation

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