Multiple functions of maspin in tumor progression and mouse development

Frontiers in Bioscience : a Journal and Virtual Library
Ming Zhang

Abstract

Maspin is a unique serpin with diverse biological functions. Initially identified from human normal mammary epithelial cells, maspin expression is either reduced or completely silenced in breast cancers. Numerous studies have implicated maspin function in cancer progression and angiogenesis. Maspin has also been targeted for breast cancer gene therapy. Recently, transgenic and gene knockout mouse models have been used by our laboratory to identify the biological functions of maspin in vivo. In this review, we summarize the multiple functions of maspin in tumor progression and mouse development. These data demonstrate that maspin not only plays a role in tumor progression and metastasis but also is a key regulatory molecule for normal mammary gland and embryonic development.

Citations

May 14, 2009·Journal of Mammary Gland Biology and Neoplasia·Christine J Watson, Peter A Kreuzaler
Mar 31, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dengfeng CaoLinus Ho
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chen ZhaoRobert M Krug
Jul 28, 2009·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Michael R MehanXianghong Jasmine Zhou
Sep 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fulvio LonardoShijie Sheng

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