Multiple genetic tests for susceptibility to smoking do not outperform simple family history

Addiction
Coral GartnerWayne Hall

Abstract

To evaluate the utility of using predictive genetic screening of the population for susceptibility to smoking. The results of meta-analyses of genetic association studies of smoking behaviour were used to create simulated data sets using Monte Carlo methods. The ability of the genetic tests to screen for smoking was assessed using receiver operator characteristic curve analysis. The result was compared to prediction using simple family history information. To identify the circumstances in which predictive genetic testing would potentially justify screening we simulated tests using larger numbers of alleles (10, 15 and 20) that varied in prevalence from 10 to 50% and in strength of association [relative risks (RRs) of 1.2-2.1]. A test based on the RRs and prevalence of five susceptibility alleles derived from meta-analyses of genetic association studies of smoking performed similarly to chance and no better than the prediction based on simple family history. Increasing the number of alleles from five to 20 improved the predictive ability of genetic screening only modestly when using genes with the effect sizes reported to date. This panel of genetic tests would be unsuitable for population screening. This situation is unlikely t...Continue Reading

References

Apr 1, 1994·Medical Hypotheses·E P NobleR S Sparkes
Mar 14, 1998·Journal of the National Cancer Institute·M R SpitzX Wu
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Jul 1, 1999·The New England Journal of Medicine·F S Collins
Jul 13, 2000·The New England Journal of Medicine·N A Holtzman, T M Marteau
Feb 24, 2001·The New England Journal of Medicine·J G Sotos, H Y Rienhoff
Aug 10, 2001·American Journal of Medical Genetics·C LermanP G Shields
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Sep 5, 2002·American Journal of Medical Genetics·Hong-Seock LeeSangduk Kim
Feb 4, 2003·Pharmacogenetics·Hidemi ItoKazuo Tajima
Feb 20, 2003·American Journal of Human Genetics·Quanhe YangW Dana Flanders
May 15, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth E Warner, David M Burns
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·E K TanY Zhao
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M Reuter, J Hennig
Jun 23, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Oct 26, 2005·Lancet·George Davey SmithPaul R Burton
Nov 2, 2005·Preventive Medicine·Kenneth P TercyakLeslie R Walker
May 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gary E SwanNeal Benowitz
May 17, 2006·The Pharmacogenomics Journal·O TrummerW Renner
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Dec 28, 2006·Respiration; International Review of Thoracic Diseases·Vincent Cottin
Dec 28, 2006·Respiration; International Review of Thoracic Diseases·Despina G Contopoulos-IoannidisJohn P A Ioannidis
May 1, 2007·Behavioral and Brain Functions : BBF·Thanh G N TonFederico M Farin
Jun 20, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Kenneth P TercyakLeslie R Walker
Dec 6, 2007·American Journal of Preventive Medicine·Caryn E LermanMarcus R Munafò
Nov 29, 2007·Addiction·David Ball
Jan 11, 2008·The New England Journal of Medicine·David J HunterJeffrey M Drazen
Jan 15, 2008·Addiction·Marcus R Munafò, Elaine C Johnstone
Jan 18, 2008·The New England Journal of Medicine·S Lilly ZhengHenrik Grönberg
Jun 7, 2008·Biological Psychiatry·Ming D LiRobert C Elston
Jun 21, 2008·The New England Journal of Medicine·Ralph J CoatesMarta Gwinn
Sep 13, 2008·Behavioral Sciences & the Law·Marko BarendregtEdwin de Beurs

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Citations

Dec 10, 2009·The American Journal of Bioethics : AJOB·Wayne Hall, Coral Gartner
Mar 3, 2011·Addiction Biology·Jessica E SturgessDaniel J Müller
Nov 10, 2011·PLoS Medicine·J Lennert Veerman
Jun 13, 2009·Future Oncology·Maya Ghoussaini, Paul D P Pharoah
Jan 13, 2009·Addiction·Marcus R Munafò
Apr 19, 2012·Addiction·Coral E GartnerBrad Partridge
May 16, 2013·Clinical Reviews in Allergy & Immunology·Michael SchivoSusan Murin

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