Multiple glomus tumors of the urinary bladder in a cow associated with bovine papillomavirus type 2 (BPV-2) infection

Veterinary Pathology
S RopertoF Roperto

Abstract

We report a case of multiple glomus tumors associated with bovine papillomavirus type 2 (BPV-2) infection in the urinary bladder of a 13-year-old cow suffering from severe chronic enzootic hematuria. Macroscopically, multiple submucosal reddish nodules were seen swelling the vesical mucosa. Histologically, neoplastic proliferation was characterized by the presence of numerous blood vessels. These were lined by normal endothelial cells surrounded by round epithelioid cells with central nuclei, prominent nucleoli, acidophilic cytoplasm, and well-defined cytoplasmic borders. Tumor cells were distributed around open vascular lumina and in perivascular spaces. They were immunohistochemically positive for actin and vimentin and negative for cytokeratins, desmin, and factor VIII-related antigen. On the basis of these findings, this tumor was diagnosed as glomus tumor, a neoplasm not previously reported in cattle and exceedingly rare in animals. BPV-2 DNA was amplified from the formalin-fixed, paraffin-processed tissue specimens obtained by laser capture microdissection. This report widens the spectrum of mesenchymal tumors of the bovine urinary bladder. Finally, the microscopic pattern of tumor described here shares striking morpholog...Continue Reading

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Citations

Jul 19, 2013·BioMed Research International·Manuela MartanoSante Roperto
Dec 29, 2009·Cancer Letters·Victor E GouldPaolo Gattuso
Feb 27, 2015·The Journal of Veterinary Medical Science·Noriyuki HoriuchiYoshiyasu Kobayashi
Jan 20, 2016·BioMed Research International·Rodrigo Pinheiro AraldiRita de Cassia Stocco
Jan 13, 2011·Veterinary Dermatology·Rachel E BurnsVerena K Affolter
Oct 13, 2009·Journal of Comparative Pathology·S RopertoF Roperto
Dec 27, 2018·Veterinary Clinical Pathology·Matthew C ReedElizabeth A Mauldin
May 16, 2008·Veterinary Research·Giuseppe Borzacchiello, Franco Roperto
Aug 31, 2018·The Journal of Veterinary Medical Science·Shinichi HatamaKoichi Kadota
Sep 29, 2018·JFMS Open Reports·Alessandro ConteStephen J Baines

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Methods Mentioned

BETA
laser-capture microdissection

Software Mentioned

Beacon Designer

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