Multiple granulocytic sarcoma during complete hematologic remission of acute nonlymphoid leukemia

Acta Haematologica
E OrlandiC Bernasconi

Abstract

In this report we describe a case of granulocytic sarcoma (GS) developing in a patient after 66 months in complete remission of acute nonlymphoid leukemia. The granulocytic precursor cell proliferation arose simultaneously in two extramedullary sites (testis and small bowel), without evidence of bone marrow relapse. The intensive systemic chemotherapy with high-dose ARA-C allowed a clinical remission, lasting 8 months. GS eventually recurred as extramedullary multi-site disease (abdominal lymph nodes, central nervous system involvement), once again unassociated with blood and bone marrow relapse. Both, at onset and in relapse, special staining techniques on tissue sections (chloroacetate esterase) and immunohistochemical typing with monoclonal antibodies were necessary for a correct diagnosis. We discuss the relationship between systemic leukemia and the GS which showed a metastasizing tumor-like behavior.

Citations

Sep 30, 2005·American Journal of Clinical Pathology·Jose R ValbuenaL Jeffrey Medeiros
Dec 16, 2006·Leukemia & Lymphoma·Semra PaydasMelek Ergin
Jul 1, 1991·Gastrointestinal Endoscopy·W M Priebe, F M Senecal
Jul 2, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J W LeeW I Yang
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria Grazia PassarinRebecca Pedersini
Jul 8, 2010·CytoJournal·Liron PantanowitzRobert A Goulart
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Shane K Kohl, Patricia Aoun

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