Multiple growth inhibition of Klebsiella pneumoniae in 1,3-propanediol fermentation

Biotechnology Letters
Ke-Ke ChengDe-hua Liu


The inhibition of substrate and product on the growth of Klebsiella pneumoniae in anaerobic and aerobic batch fermentation for the production of 1,3-propanediol was studied. The cells under anaerobic conditions had a higher maximum specific growth rate of 0.19 h(-1) and lower tolerance to 110 g glycerol l(-1), compared to the maximum specific growth rate of 0.17 h(-1) and tolerance to 133 g glycerol l(-1) under aerobic conditions. Acetate was the main inhibitory metabolite during the fermentation under anaerobic conditions, with lactate and ethanol the next most inhibitory. The critical concentrations of acetate, lactate and ethanol were assessed to be 15, 19, 26 g l(-1), respectively. However, cells grown under aerobic conditions were more resistant to acetate and lactate but less resistant to ethanol. The critical concentrations of acetate, lactate and ethanol were assessed to be 24, 26, and 17 g l(-1), respectively.


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