Multiple growth inhibition of Klebsiella pneumoniae in 1,3-propanediol fermentation

Biotechnology Letters
Ke-Ke ChengDe-hua Liu

Abstract

The inhibition of substrate and product on the growth of Klebsiella pneumoniae in anaerobic and aerobic batch fermentation for the production of 1,3-propanediol was studied. The cells under anaerobic conditions had a higher maximum specific growth rate of 0.19 h(-1) and lower tolerance to 110 g glycerol l(-1), compared to the maximum specific growth rate of 0.17 h(-1) and tolerance to 133 g glycerol l(-1) under aerobic conditions. Acetate was the main inhibitory metabolite during the fermentation under anaerobic conditions, with lactate and ethanol the next most inhibitory. The critical concentrations of acetate, lactate and ethanol were assessed to be 15, 19, 26 g l(-1), respectively. However, cells grown under aerobic conditions were more resistant to acetate and lactate but less resistant to ethanol. The critical concentrations of acetate, lactate and ethanol were assessed to be 24, 26, and 17 g l(-1), respectively.

References

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Jul 23, 2004·Biotechnology Letters·Ke-Ke ChengWei-Bin Liu

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Citations

Apr 9, 2009·Applied Microbiology and Biotechnology·Kouta Hatayama, Tatsuo Yagishita
Jul 19, 2011·Bioprocess and Biosystems Engineering·Kaloyan Petrov, Anton Stoyanov
Feb 7, 2012·Bioprocess and Biosystems Engineering·Jung-Hee ChoDoyoung Seung
Apr 3, 2010·Journal of Industrial Microbiology & Biotechnology·Xuedong XueQin Ye
Jan 19, 2012·Journal of Industrial Microbiology & Biotechnology·Daniele Misturini RossiMarco Antônio Záchia Ayub
Aug 17, 2006·Biotechnology Letters·Ke-Ke ChengJing-Ming Xu
Jul 31, 2013·Applied Biochemistry and Biotechnology·Shengguo LuHe Huang
Jul 31, 2013·Bioprocess and Biosystems Engineering·Fatma Gizem AvciNuri Azbar
Jan 29, 2013·Applied Biochemistry and Biotechnology·Daniele Misturini RossiMarco Antônio Záchia Ayub
Sep 9, 2008·Biotechnology Advances·Gervásio Paulo da SilvaJonas Contiero
May 29, 2007·Current Opinion in Biotechnology·Syed Shams Yazdani, Ramon Gonzalez
Nov 9, 2010·Biotechnology Journal·Hongjuan LiuDehua Liu
Aug 25, 2015·Bioprocess and Biosystems Engineering·Soojin LeeJinwon Lee
Jul 5, 2016·Scientific Reports·Alice Julien-LaferrièreMarie-France Sagot
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Oct 15, 2011·Critical Reviews in Biotechnology·E Celińska
Jul 24, 2020·Applied Biochemistry and Biotechnology·Vanessa Zimmer da SilvaMarco Antonio Zachia Ayub
Dec 22, 2019·Applied Biochemistry and Biotechnology·Wei-Chuan ChenYu-Hong Wei
Jun 11, 2019·Frontiers in Bioengineering and Biotechnology·Carsten JersIvan Mijakovic
May 31, 2007·Chemical Reviews·Avelino CormaAlexandra Velty

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