PMID: 9529314May 16, 1998Paper

Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

The Journal of Experimental Medicine
D CarrascoR Bravo

Abstract

The c-rel protooncogene encodes a member of the Rel/nuclear factor (NF)-kappaB family of transcriptional factors. To assess the role of the transcriptional activation domain of c-Rel in vivo, we generated mice expressing a truncated c-Rel (Deltac-Rel) that lacks the COOH-terminal region, but retains a functional Rel homology domain. Mice with an homozygous mutation in the c-rel region encoding the COOH terminus of c-Rel (c-relDeltaCT/DeltaCT) display marked defects in proliferative and immune functions. c-relDeltaCT/DeltaCT animals present histopathological alterations of hemopoietic tissues, such as an enlarged spleen due to lymphoid hyperplasia, extramedullary hematopoiesis, and bone marrow hypoplasia. In older c-relDeltaCT/DeltaCT mice, lymphoid hyperplasia was also detected in lymph nodes, liver, lung, and stomach. These animals present a more severe phenotype than mice lacking the entire c-Rel protein. Thus, in c-relDeltaCT/DeltaCT mice, the lack of c-Rel activity is less efficiently compensated by other NF-kappaB proteins.

References

Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Feb 1, 1992·Molecular and Cellular Biology·R P RyseckR Bravo
Jan 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R KlingelH Köhler
Jun 1, 1991·Journal of Virology·P M Richardson, T D Gilmore
Sep 1, 1991·The British Journal of Ophthalmology·H A QuigleyM E Dorman-Pease
Jul 1, 1984·The Journal of Experimental Medicine·S A FischkoffT J Reber
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Nov 15, 1995·Genes & Development·I M VermaS Miyamoto
Sep 1, 1995·Molecular and Cellular Biology·C C ChangR Dalla-Favera
Jan 1, 1995·Advances in Immunology·E B Kopp, S Ghosh
Feb 1, 1995·Current Opinion in Immunology·S GordonA Doyle
Feb 24, 1995·Cell·D Thanos, T Maniatis
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G J ThorbeckeV K Tsiagbe
Jun 1, 1993·Current Opinion in Cell Biology·H C Liou, D Baltimore
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·S GerondakisR J Grumont
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Dec 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F G WulczynC Scheidereit
Mar 1, 1997·Current Biology : CB·D Tarlinton
Apr 1, 1997·Seminars in Cancer Biology·R M AttarR Bravo
Nov 14, 1997·Nature Medicine·V IotsovaR Bravo
Feb 1, 1991·Current Biology : CB·C Dingwall

❮ Previous
Next ❯

Citations

Mar 29, 2002·Genes, Chromosomes & Cancer·Demetrios Kalaitzidis, Thomas D Gilmore
Jan 22, 2004·Current Opinion in Immunology·Anne PuelJean-Laurent Casanova
Nov 26, 2010·Cell Research·Vincent Feng-Sheng ShihAlexander Hoffmann
Jan 19, 2011·Cell Research·Matthew S Hayden, Sankar Ghosh
Oct 31, 2006·Oncogene·M S HaydenS Ghosh
Sep 22, 1998·The Journal of Experimental Medicine·J D ChengR Bravo
Jul 5, 2002·Clinical Microbiology Reviews·Jorge Caamaño, Christopher A Hunter
Feb 24, 2011·Infection and Immunity·Emilie CourtineJean-Paul Mira
Feb 28, 2002·Annual Review of Immunology·Tasuku HonjoMasamichi Muramatsu
Jun 25, 2014·Seminars in Immunology·Matthew S Hayden, Sankar Ghosh
Dec 29, 2004·FEBS Letters·Kazuyuki IwaiMakio Iwashima
Jan 1, 2016·Trends in Pharmacological Sciences·M Lienhard Schmitz, Michael Kracht
Nov 18, 2004·Immunological Reviews·Kerri A Mowen, Laurie H Glimcher
Mar 23, 2012·Immunological Reviews·Sankar Ghosh, Matthew S Hayden
Dec 2, 2009·European Journal of Immunology·Elissa K DeenickPamela S Ohashi
Nov 19, 2013·European Journal of Immunology·Branislav KrljanacFalk Weih
Apr 5, 2005·Immunobiology·Robson Coutinho-SilvaGeoffrey Burnstock
Apr 10, 2016·Annals of Intensive Care·Julie ToubianaJean-Paul Mira
Nov 2, 2014·Cell Death and Differentiation·L A O'ReillyA Strasser
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Emanuela Castigli, Raif S Geha
Dec 1, 2001·Nature Medicine·T LawrenceD A Willoughby
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Sep 1, 2008·Expert Review of Clinical Immunology·Lianping Xing, Rui-Cheng Ji
Mar 5, 2020·Cellular and Molecular Life Sciences : CMLS·Shrikanth C Basavarajappa, Parameswaran Ramakrishnan
Feb 3, 2004·Oncogene·Thomas D GilmoreDaniel T Starczynowski
Dec 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peishan LeeRobert C Rickert
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S GuerderA M Schmitt-Verhulst
Jul 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guobing ChenM Frances Shannon
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy L McCartney-Francis, Sharon M Wahl
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D S WeihF Weih
Jan 19, 2021·Nature Cancer·Ting LiYouhai H Chen
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh

❮ Previous
Next ❯

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