Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum

IMA Fungus
Stephanie Van WykEmma T Steenkamp

Abstract

Fusarium is a diverse assemblage that includes a large number of species of considerable medical and agricultural importance. Not surprisingly, whole genome sequences for many Fusarium species have been published or are in the process of being determined, the availability of which is invaluable for deciphering the genetic basis of key phenotypic traits. Here we investigated the distribution, genic composition, and evolutionary history of a locus potentially determining growth rate in the pitch canker pathogen F. circinatum. We found that the genomic region underlying this locus is highly conserved amongst F. circinatum and its close relatives, except for the presence of a 12 000 base pair insertion in all of the examined isolates of F. circinatum. This insertion encodes for five genes and our phylogenetic analyses revealed that each was most likely acquired through horizontal gene transfer from polyphyletic origins. Our data further showed that this region is located in a region low in G+C content and enriched for repetitive sequences and transposable elements, which is situated near the telomere of Chromosome 3 of F. circinatum. As have been shown for other fungi, these findings thus suggest that the emergence of the unique 12...Continue Reading

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Datasets Mentioned

BETA
PRJNA41113
AYJV00000000.2
LQBB00000000

Methods Mentioned

BETA
PCRs
PCR

Software Mentioned

BLAST
CLC Main Workbench
COBALT ( Constraint - based Multiple Protein Alignment Tool )
ABySS
AFLPinSilico
Antibiotics and Secondary Metabolites Analysis Shell ( antiSMA...
InterProScan
CLC Genomics Workbench
MEGA
Primer3

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