PMID: 2500442Jun 1, 1989Paper

Multiple inducers of the Drosophila heat shock locus 93D (hsr omega): inducer-specific patterns of the three transcripts

The Journal of Cell Biology
W G BendenaM L Pardue

Abstract

The Drosophila hsr omega locus produces one of the largest and most active heat shock puffs, yet it does not encode a heat shock protein. Instead, this locus produces a distinctive set of three transcripts, all from the same start site. The largest transcript, omega 1, is limited to the nucleus and appears to have a role there. A second nuclear transcript, omega 2, is produced by alternative termination and contains the sequence found in the 5' 20-25% of omega 1 (depending on the Drosophila species). The cytoplasmic transcript, omega 3, is produced by removal of a 700-bp intron from omega 2. All three hsr omega RNAs are produced constitutively and production is enhanced by heat shock. In addition to being a member of the set of heat shock puffs, the hsr omega puff is induced by agents that do not affect other heat shock loci, suggesting that hsr omega is more sensitive to environmental changes than other loci. We report here that agents that induce puffing of hsr omega loci in polytene nuclei also lead to an increase in hsr omega transcripts in diploid cells. We also show that the relative levels of omega 1 and omega 3 can be modulated independently by several agents. All drugs that inhibit translation, either initiation or elo...Continue Reading

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Citations

Sep 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A Sharma, S C Lakhotia
May 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·S C Lakhotia, A Sharma
Jul 30, 2011·Journal of Biosciences·Subhash C Lakhotia
Mar 13, 2009·Cell Stress & Chaperones·Travis K JohnsonStephen W McKechnie
May 18, 2007·Annual Review of Cell and Developmental Biology·Mary-Lou Pardue
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S W McKechnieA A Hoffmann
Jun 8, 1993·The Journal of Comparative Neurology·S S KanekarJ D Coulter
Jul 6, 2015·Biochimica Et Biophysica Acta·Timothy E Audas, Stephen Lee
Sep 15, 2012·Wiley Interdisciplinary Reviews. RNA·Subhash C Lakhotia
Aug 17, 2016·Journal of Cell Science·Anshika GoenkaSubramaniam Ganesh
Nov 21, 1992·Annals of the New York Academy of Sciences·M L PardueN C Hogan

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