Multiple interests in structural models of DARC transmembrane protein

Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
D SmolarekA G de Brevern

Abstract

Duffy Antigen Receptor for Chemokines (DARC) is an unusual transmembrane chemokine receptor which (i) binds the two main chemokine families and (ii) does not transduct any signal as it lacks the DRY consensus sequence. It is considered as silent chemokine receptor, a tank useful for chemiotactism. DARC had been particularly studied as a major actor of malaria infection by Plasmodium vivax. It is also implicated in multiple chemokine inflammation, inflammatory diseases, in cancer and might play a role in HIV infection and AIDS. In this review, we focus on the interest to build structural model of DARC to understand more precisely its abilities to bind its physiological ligand CXCL8 and its malaria ligand. We also present innovative development on VHHs able to bind DARC protein. We underline difficulties and limitations of such bioinformatics approaches and highlight the crucial importance of biological data to conduct these kinds of researches.

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Citations

Jun 28, 2011·British Journal of Pharmacology·D J ScholtenR Leurs
Jun 16, 2015·Frontiers in Molecular Biosciences·Pierrick CraveurAlexandre G de Brevern
Feb 22, 2011·Journal of Theoretical Biology·Alexandre G de Brevern, Agnel Praveen Joseph
Sep 11, 2016·Biochimie·Floriane NoëlAlexandre G de Brevern
Mar 30, 2010·Amino Acids·Jean PylousterAlexandre G de Brevern
Mar 19, 2020·PeerJ·Akhila Melarkode VattekatteAlexandre G de Brevern

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