Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies

Journal of the American Academy of Dermatology
Steven M RuhoyGerard J Nuovo

Abstract

Inverted follicular keratosis is characterized by a squamous epithelial expansion of the infundibular portion of the hair follicle in an exophytic and endophytic pattern. The lesion is often associated with squamous eddies similar to an irritated keratosis and may have a superficial papillomatous architecture. The lesion most often arises as a solitary nodule on the face of middle age to elderly individuals. Inverted follicular keratosis has been described as a distinct entity by some while others believe that it is related to trichilemmomas and/or verruca vulgares. The cutaneous pathology of Cowden's syndrome is characterized by multiple trichilemmomas. We present a woman who fulfills the clinical criteria for Cowden's syndrome and who initially presented with multiple inverted follicular keratoses. Also, in situ hybridization studies performed on the patient's keratoses do not reveal evidence of human papillomavirus infection.

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Citations

Mar 2, 2012·Journal of Maxillofacial and Oral Surgery·Rohit SharmaP Suresh Menon
Aug 1, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrea Bolzoni VillaretAlfred Aga
Feb 8, 2007·The American Journal of Dermatopathology·Hye-Ja ChoiChull-Wan Ihm
Jun 14, 2016·Indian Dermatology Online Journal·Ayse Serap KaradagBerkant Oman
Jun 14, 2016·Indian Dermatology Online Journal·Yulia GrayDirk M Elston
Oct 11, 2008·Journal of Cutaneous Medicine and Surgery·Kristin Noiles, Ronald Vender
Sep 10, 2009·Clinical and Experimental Immunology·A V MarzanoM Cugno
Sep 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·J Kanitakis
Mar 21, 2012·Head & Neck·Joseph E HallRobert J Sinard
Jan 4, 2019·Japanese Journal of Ophthalmology·Cecilia Díez-MonteroAlicia Galindo-Ferreiro

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