PMID: 2887104Aug 1, 1987Paper

Multiple islet cell tumors with predominance of glucagon-producing cells and ulcer disease

American Journal of Clinical Pathology
Cesare BordiA Peracchia

Abstract

Two cases of multiple islet cell tumors mostly composed of glucagon-producing cells and associated with severe ulcer disease are presented. Multiple endocrine neoplasia type I (MEN-I) was present in both patients, although symptomatically latent in case 2. Immunohistochemistry showed that glucagon (A) cells were a major cell population (i.e., accounting for at least 30% of the tumor cell population) in 24 of 43 tumors (either macroadenomas or microadenomas) studied in case 1 and in 12 of 17 tumors studied in case 2. A major pancreatic polypeptide (PP) cell population was found in 12 and 7 tumors of case 1 and 2, respectively. In contrast, insulin (B) and somatostatin (D) cells were scarce in most adenomas. Gastrin-producing cells were not identified in any tumors, despite the use of different antigastrin antisera. Extrapancreatic or residual gastrinomas were not found at postmortem examination in case 1 or on appropriate surgical inspection done 24 years after the onset of the ulcer disease in patient 2. On the basis of these and of 17 additional cases collected in the literature, it is concluded that multiple A-cell tumors of the pancreas are an expression of the MEN-I and are mostly associated with ulcer disease and/or with h...Continue Reading

Citations

Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Günter KlöppelPaul Komminoth
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·C AzzoniC Bordi
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiT D'Adda
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiC Betterle
Mar 15, 1990·The New England Journal of Medicine·M Pipeleers-MarichalP U Heitz
May 16, 2006·The American Journal of Surgical Pathology·Martin AnlaufGünter Klöppel
Dec 1, 1996·Baillière's Clinical Gastroenterology·A E Bishop, J M Polak

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