PMID: 9418956Jan 7, 1998Paper

Multiple isoforms of neuregulin are expressed in developing rat dorsal root ganglia

Journal of Neuroscience Research
J ShinodaK Uyemura

Abstract

Accumulating evidence suggests that neuregulin (NRG) plays special roles in the development of the mammalian nervous system. We have already identified NRG as a survival factor for Schwann cells during development. In this report, we have studied all possible NRG isoforms and expression of NRG in the developing rat dorsal root ganglia (DRG) and compared them with those of brain and spinal cord. Neural NRG isoforms comprise common immunoglobulin and epidermal growth factor domains. Various different transcripts were characterized, which arose by alternative splicing in several regions: N-terminal (exon 1 or 2), spacer (exon 5), juxtamembrane (exon 9 or 10), and cytoplasmic (exon 12, 13, or 14) domains. At least 13 novel isoforms among 16 splice variants were identified. The transmembrane isoforms of NRG are dominant forms in developing rat DRG. The mRNA expression of NRG isoforms in DRG is similar to that in spinal cord, while in brain the expression is much less. The mRNA in DRG was found at similar levels from birth to postnatal day 7 of the premyelinating stage, and it decreased afterward. Our results suggest that several NRGs, including isoforms not reported before, play a role as survival factors for Schwann cells in the pr...Continue Reading

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Citations

Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junji YamauchiEric M Shooter
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Margarita CalvoDavid L H Bennett
Mar 21, 2001·The Journal of Cell Biology·G ZanazziJ L Salzer
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M Ozaki
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K FriedC Lillesaar
Feb 25, 2000·Journal of Neuroscience Research·M OzakiT Hashikawa
Jul 6, 2000·Journal of Neuroscience Research·R J ThompsonS C Barnett

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