Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy

Journal of Cutaneous Pathology
Benjamin J KahnTravis W Blalock

Abstract

We present histologic features of a locally advanced cutaneous squamous cell carcinoma (cSCC) treated with the programmed cell death protein-1 (PD-1) antagonist, pembrolizumab, with a partial response. This contributes to a growing body of literature supporting the efficacy of pembrolizumab in treatment of surgically unresectable cSCC. We also provide a detailed description of the histologic features, particularly keratin granulomata with adjacent lymphocytic aggregates and fibrosis, observed in cSCC under treatment with a PD-1 antagonist.

References

Sep 14, 2013·Carcinogenesis·Eduardo Bertoli BelaiAna Paula Campanelli
Oct 18, 2016·The British Journal of Dermatology·J K WinklerJ C Hassel
May 7, 2016·Journal of Cutaneous Pathology·Nathaniel A Slater, Paul B Googe
May 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lawrence H SchwartzLesley Seymour
May 31, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·E DegacheJ Charles
Jul 19, 2017·Journal of the American Academy of Dermatology·Juana María García-PedreroJorge Santos-Juanes
Jan 16, 2018·Journal of the American Academy of Dermatology·Syril Keena T QueChrysalyne D Schmults

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