Multiple large inversions and breakpoint rewiring of gene expression in the evolution of the fire ant social supergene

Proceedings. Biological Sciences
Yu-Ching HuangJohn Wang

Abstract

Supergenes consist of co-adapted loci that segregate together and are associated with adaptive traits. In the fire ant Solenopsis invicta, two 'social' supergene variants regulate differences in colony queen number and other traits. Suppressed recombination in this system is maintained, in part, by a greater than 9 Mb inversion, but the supergene is larger. Has the supergene in S. invicta undergone multiple large inversions? The initial gene content of the inverted allele of a supergene would be the same as that of the wild-type allele. So, how did the inversion increase in frequency? To address these questions, we cloned one extreme breakpoint in the fire ant supergene. In doing so, we found a second large (greater than 800 Kb) rearrangement. Furthermore, we determined the temporal order of the two big inversions based on the translocation pattern of a third small fragment. Because the S. invicta supergene lacks evolutionary strata, our finding of multiple inversions may support an introgression model of the supergene. Finally, we showed that one of the inversions swapped the promoter of a breakpoint-adjacent gene, which might have conferred a selective advantage relative to the non-inverted allele. Our findings provide a rare...Continue Reading

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Citations

May 23, 2019·Genome Biology and Evolution·Vinicius H da SilvaMartien A M Groenen
Jan 22, 2020·Nature Ecology & Evolution·Zheng YanLaurent Keller
Apr 20, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yupeng PanYiqun Weng
Aug 5, 2020·Molecular Ecology·Samuel V ArsenaultBrendan G Hunt
Apr 1, 2021·Molecular Ecology·Romain VilloutreixPatrik Nosil
Mar 20, 2021·Genome Biology and Evolution·Juanita Gutiérrez-ValenciaTanja Slotte
Jun 22, 2021·Frontiers in Genetics·Jasmine L LovelandClemens Küpper

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