Multiple Lesions Insertion: boosting diabetic retinopathy screening through Poisson editing.

Biomedical Optics Express
Zekuan YuYanye Lu

Abstract

Deep neural networks have made incredible progress in many computer vision tasks, owing to access to a great amount of data. However, collecting ground truth for large medical image datasets is extremely inconvenient and difficult to implement in practical applications, due to high professional requirements. Synthesizing can generate meaningful supplement samples to enlarge the insufficient medical image dataset. In this study, we propose a new data augmentation method, Multiple Lesions Insertion (MLI), to simulate new diabetic retinopathy (DR) fundus images based on the healthy fundus images that insert real lesions, such as exudates, hemorrhages, microaneurysms templates, into new healthy fundus images with Poisson editing. The synthetic fundus images can be generated according to the clinical rules, i.e., in different DR grading fundus images, the number of exudates, hemorrhages, microaneurysms are different. The generated DR fundus images by our MLI method are realistic with the real texture features and rich details, without black spots, artifacts, and discontinuities. We first demonstrate the feasibility of this method in a DR computer-aided diagnosis (CAD) system, which judges whether the patient has transferred treatmen...Continue Reading

References

Dec 25, 2003·Diabetes Care·Donald S FongUNKNOWN American Diabetes Association
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Apr 16, 2004·IEEE Transactions on Medical Imaging·Joes StaalBram van Ginneken
Jun 17, 2015·IEEE Transactions on Bio-medical Engineering·Aria PezeshkNicholas Petrick
Jun 14, 2016·IEEE Transactions on Pattern Analysis and Machine Intelligence·Shaoqing RenJian Sun
Nov 30, 2016·JAMA : the Journal of the American Medical Association·Varun GulshanDale R Webster
Jan 24, 2017·IEEE Transactions on Medical Imaging·Aria PezeshkBerkman Sahiner
Oct 6, 2017·IEEE Transactions on Medical Imaging·Pedro CostaAurelio Campilho
Jul 15, 2018·Medical Image Analysis·He ZhaoLi Cheng
Sep 21, 2018·Biomedical Engineering Online·Zhe JiangYanye Lu
May 23, 2019·Biomedical Engineering Online·Zekuan YuYanye Lu
Jan 7, 2020·Neurospine·Mingyu KimNamkug Kim

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