PMID: 7526380Nov 8, 1994Paper

Multiple ligands for cytoadherence can be present simultaneously on the surface of Plasmodium falciparum-infected erythrocytes

Proceedings of the National Academy of Sciences of the United States of America
S C ChaiyarojG V Brown

Abstract

A major virulence factor of Plasmodium falciparum is the adherence of parasitized erythrocytes to the wall of postcapillary venules via a specific interaction between parasite-derived erythrocyte surface ligands and receptors on endothelial cells. To study this phenomenon in vitro, we selected a parasite population that expressed at least two different ligands and demonstrated that parasitized cells may coexpress ligands with specificity for multiple receptors. This selected parasite line had several antigenic and cytoadherence characteristics that were different from those of the parent line. Single parasitized erythrocytes were able to adhere to three distinct receptors via at least two separate ligands; a trypsin-sensitive molecule mediated cytoadherence to CD36 and intercellular adhesion molecule 1 and a trypsin-insensitive molecule(s) was responsible for adherence to a third receptor on the surface of melanoma cells. We present evidence that this newly discovered receptor for cytoadherence is an N-linked glycosaminoglycan, as treatment of melanoma cells with endoglycosidase H abolished cytoadherence. These observations emphasize the adaptability of P. falciparum and the complexity of the cytoadherence phenomenon.

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Citations

Oct 1, 1995·Parasitology Today·I W ShermanK M Land
Sep 10, 1999·International Journal for Parasitology·C NewboldT Fagan
May 30, 2001·Molecular and Biochemical Parasitology·R NoviyantiJ C Reeder
Mar 6, 1999·Current Opinion in Microbiology·R L CoppelV Nussenzweig
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·D I BaruchB L Pasloske
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·J P GardnerC I Newbold
Jul 1, 1995·The Journal of Experimental Medicine·S J RogersonG V Brown
Jan 1, 1997·Brain Pathology·G Turner
Jul 25, 2000·Clinical Microbiology Reviews·Q ChenM Wahlgren
Dec 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Toshimitsu HatabuShigeyuki Kano
Apr 25, 2009·Journal of Molecular Biology·Michael F DuffyGraham V Brown
Jan 24, 2007·Advances in Pharmacology·D Channe Gowda
Oct 20, 2018·The Journal of Infectious Diseases·Ana CabreraKevin C Kain
May 11, 2017·Malaria Journal·Casper HempelTrine Staalsø

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