Multiple mechanisms of protein insertion into and across membranes

Science
W Wickner, H F Lodish

Abstract

Protein localization in cells is initiated by the binding of characteristic leader (signal) peptides to specific receptors on the membranes of mitochondria or endoplasmic reticulum or, in bacteria, to the plasma membrane. There are differences in the timing of protein synthesis and translocation into or across the bilayer and in the requirement for a transmembrane electrochemical potential. Comparisons of protein localization in these different membranes suggest underlying common mechanisms.

Citations

Jan 1, 1993·Archives of Insect Biochemistry and Physiology·E P MaslerJ J Menn
Oct 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S F Nothwehr, J I Gordon
Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C HughesV Koronakis
Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S High
Jul 1, 1991·Biotechnology and Bioengineering·A SambanisG Stephanopoulos
Jan 1, 1991·Journal of Electron Microscopy Technique·A R Beaudoin, G Grondin
Jul 1, 1988·Photosynthesis Research·T H LubbenK Keegstra
Sep 1, 1989·Molecular & General Genetics : MGG·J C LazzaroniR Portalier
Feb 1, 1988·Biochemical Genetics·L R Munneke, G E Collier
Jan 1, 1988·Molecular Biology Reports·J L BoccoL C Patrito
Mar 1, 1990·The Journal of Membrane Biology·J O BullockM A McIntosh
Jun 15, 1990·Experientia·M P Reinhart
May 1, 1995·Applied Biochemistry and Biotechnology·H WangU J Krull
Jan 1, 1987·Immunologic Research·D H MarguliesJ McCluskey
Oct 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N Schweifer, D P Barlow
Jan 4, 1994·Biochimica Et Biophysica Acta·R PalmenK J Hellingwerf
Oct 16, 1987·Biochimica Et Biophysica Acta·R NagarajG L Reddy
Oct 10, 1991·Biochimica Et Biophysica Acta·R G Shatters, J A Miernyk
Dec 15, 1986·Biochemical Pharmacology·P De Camilli, P Greengard
Apr 1, 1993·Comparative Immunology, Microbiology and Infectious Diseases·L E Samartino, F M Enright
Jan 1, 1987·Pharmacology & Therapeutics·R DatemaP A Romero
Jan 1, 1991·Progress in Lipid Research·J BorénS O Olofsson
Aug 1, 1987·Molecular and Biochemical Parasitology·R A Aman, C C Wang
Dec 1, 1991·Molecular and Biochemical Parasitology·F M TomleyJ J Kok
Feb 1, 1995·Virus Research·U HoferK Ballmer-Hofer
Jun 9, 1988·Biochimica Et Biophysica Acta·G von Heijne
Jan 18, 1989·Biochimica Et Biophysica Acta·F U HartlW Neupert
Dec 6, 1989·Biochimica Et Biophysica Acta·M G Low
Nov 25, 1987·Biochimica Et Biophysica Acta·W Markland, A E Smith
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A C LeBlanc, C Mezei
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Grossman
Jan 1, 1986·Gene·L W CohenL C Dihel
Nov 30, 1988·Gene·A M van der BliekP Borst
Jul 1, 1988·Trends in Biochemical Sciences·T R Hirst, R A Welch
Sep 1, 1994·Trends in Biochemical Sciences·N PfannerM Meijer
Aug 1, 1995·Quarterly Reviews of Biophysics·R Grisshammer, C G Tate
Apr 1, 1996·Nature Genetics·S BioneD Toniolo
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M RomeoD R Zusman
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P A Maher, S J Singer
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N Sivasubramanian, D P Nayak
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A GonzalezT Gottlieb
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E Crooke, W Wickner
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P OverathJ K Wright
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R W JackmanR D Rosenberg
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T R Hirst, J Holmgren
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J P Fandl, P C Tai
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R FittsD Botstein
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L T Bracey, K Paigen
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M D MooreG R Nemerow
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S J SingerM P Yaffe
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T Brismar, W F Gilly
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A Alonso, S M Weissman
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G von HeijneR E Dalbey
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A ShippE L Reinherz
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H K SarkarH R Kaback
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A S ShawJ K Rose
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D HereldP T Englund
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E Szczesna-SkorupaB Kemper
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C Abeijon, C B Hirschberg
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J DiamondE L Reinherz
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K ChaudharyI Pastan
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H B Pollard, E Rojas
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A ShippE L Reinherz
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C A Kumamoto
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E HartmannH F Lodish
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R D LarsenJ B Lowe
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K Cunningham, W Wickner
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R D LarsenJ B Lowe
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R KumarP Stanley
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R AllredA F Barbet
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E BibiH R Kaback
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Roemer, H Bussey
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M SakaguchiT Omura
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Milik, J Skolnick
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M BlackW L Miller
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·K NaraY Sanai
May 16, 2008·The Journal of Biological Chemistry·Hindupur K AnandatheerthavaradaN G Avadhani
Feb 1, 1990·Journal of Biomolecular Structure & Dynamics·V N ViswanadhanP C Elwood
Jan 1, 1988·The Journal of Cell Biology·M DuszenkoG A Cross
May 1, 1988·The Journal of Cell Biology·F J ZimmerP Hausen
Jun 1, 1988·The Journal of Cell Biology·J Lipp, B Dobberstein
Dec 1, 1990·The Journal of Cell Biology·H F StegerN Pfanner
Dec 1, 1991·The Journal of Cell Biology·U WienhuesW Neupert
Dec 1, 1992·The Journal of Cell Biology·H M McBrideG C Shore
Mar 1, 1992·The Journal of Experimental Medicine·Y ChoiJ W Kappler
Jan 11, 1988·Nucleic Acids Research·M HortschD I Meyer
Apr 1, 1989·Plant Physiology·S K Randall, H Sze
Sep 1, 1991·Molecular Microbiology·K Ito, Y Akiyama
Mar 2, 1987·European Journal of Biochemistry·M F Petit-GlatronR Chambert
Aug 1, 1988·European Journal of Biochemistry·N PfannerW Neupert
Sep 11, 1990·European Journal of Biochemistry·K MahlkeW Neupert
Jan 1, 1990·The European Journal of Neuroscience·Thomas A. RhynerJacques Mallet
Dec 31, 1992·Annals of the New York Academy of Sciences·R Gilmore, K V Kellaris
Apr 15, 1994·Annals of the New York Academy of Sciences·P LuporiniR A Bradshaw
Mar 1, 1989·The Journal of Clinical Investigation·V R Lingappa
Apr 1, 1989·The Journal of Clinical Investigation·A T LookS C Peiper
Dec 3, 1999·Biochemical and Biophysical Research Communications·M UrabeK Ozawa
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·A ZelaznyE Bibi
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·D ZhangP J Godowski
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Sichen Shao, Ramanujan S Hegde
Oct 1, 1990·Antonie van Leeuwenhoek·N PfannerW Neupert
Feb 1, 1992·Antonie van Leeuwenhoek·P KeilN Pfanner
Jul 1, 1989·Trends in Biochemical Sciences·H Neurath
Sep 1, 1988·Trends in Biochemical Sciences·S OlsnesK Sandvig
Jun 6, 1994·FEBS Letters·B JungnickelE Hartmann
Jun 6, 1994·FEBS Letters·C Peters, K von Figura
Jan 1, 1989·Critical Reviews in Biotechnology·V S Bisaria, S Mishra
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·P Silver, H Goodson
Aug 1, 1990·FEBS Letters·C J Lazdunski, H Benedetti
Mar 17, 1986·FEBS Letters·G von Heijne
Jan 15, 1995·European Journal of Biochemistry·G C ShoreM Nguyen
Mar 15, 2016·Frontiers in Bioengineering and Biotechnology·Christine SchmittLars M Voll
May 2, 2009·Molecular Immunology·Theresa E SingletonEdda Fiebiger
May 16, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Charoonroj ChotwiwatthanakunSarawut Jitrapakdee
Jun 18, 1993·Biochimica Et Biophysica Acta·S F GreenhutM A Roseman
Jul 13, 1990·Cell·T SöllnerW Neupert
Jul 24, 1992·Cell·O SchneewindV A Fischetti
Mar 1, 1990·Microbial Pathogenesis·S OlsnesK Sandvig
Jan 1, 1987·Annals of the New York Academy of Sciences·C C Glembotski
Jul 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Keegstra, C Bauerle
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A RothschildS S Schreiber
Mar 1, 1988·Molecular Microbiology·B L PasloskeW Paranchych
Jan 1, 1987·Annals of the New York Academy of Sciences·A HeleniusI Mellman
Jan 1, 1986·Journal of Cellular Biochemistry·H Neurath
Jan 1, 1987·Annals of the New York Academy of Sciences·M A RothschildS S Schreiber
Nov 26, 1986·Biochemical and Biophysical Research Communications·B L SlomianyA Slomiany
Jun 16, 1988·Biochemical and Biophysical Research Communications·M Sagstetter, R Zimmermann
Jun 16, 1988·Biochemical and Biophysical Research Communications·L E Grosso, R P Mecham
Aug 1, 1991·International Journal of Biological Macromolecules·J J PerezJ Masip
Nov 8, 2011·Plant Signaling & Behavior·Christiaan van der SchootPäivi L H Rinne
Jul 22, 2009·Biochimica Et Biophysica Acta·Latha Devi, Hindupur K Anandatheerthavarada
Jan 12, 1996·Biochimica Et Biophysica Acta·K M Taylor, M A Roseman
Feb 29, 1988·Biochemical and Biophysical Research Communications·G J StrousE G Berger
Feb 7, 1989·Biochemistry·L M Gierasch
Aug 14, 1986·Nature·D S GoldfarbR D Kornberg
Mar 13, 1995·Physical Review Letters·A Baumgärtner, J Skolnick
Jan 1, 1990·Critical Reviews in Clinical Laboratory Sciences·M ZaidiL H Breimer
Jan 1, 1986·Endocrine Research·C R JefcoateM J DiBartolomeis
Jan 1, 1993·Microbiology and Immunology·H YamanakaK Okamoto
Sep 1, 1990·Molecular & General Genetics : MGG·J M van DijlG Venema
Jun 21, 1996·The Journal of Biological Chemistry·J Krijnse-LockerG Griffiths
May 19, 1995·The Journal of Biological Chemistry·N ToyodaP R Larsen
Oct 24, 2001·The Journal of Biological Chemistry·Ben M AbellMaurice M Moloney
Jul 22, 1996·Physical Review Letters·W Sung, P J Park
Jun 29, 2006·Physical Review Letters·Joanne Klein WolterinkDebabrata Panja
Jul 15, 1989·European Journal of Biochemistry·G D'AgostaroM Tropak
Aug 15, 2018·International Journal of Molecular Sciences·Young-Jin ParkWon-Sik Kong
Jan 1, 1987·Annals of the New York Academy of Sciences·K M WirenH M Kronenberg
Jul 24, 2001·Oncogene·M Scherl-MostageerN Schweifer

Related Concepts

Metazoa
Endoplasmic Reticulum
Red Cell Ghost
Intracellular Membranes
Cell Surface Proteins
Tissue Membrane
Mitochondria
Ribosomes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.