PMID: 9548971Jun 13, 1998Paper

Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs

Genome Research
Margaret S HalleckR A Schlegel

Abstract

The Saccharomyces cerevisiae genome contains five P-type ATPases divergent from both of the well-known subfamilies of these membrane ion transporters. This newly recognized third subfamily can be further divided into four classes of genes with nearly equal relatedness to each other. Genes of this new subfamily are also present and expressed in multicellular organisms such as Caenorhabditis elegans and mammals; some, but not all, can be assigned to the classes identified in yeast. Different classes of genes and different genes within a class are expressed differentially in tissues of the mouse. The recently cloned gene for the mammalian aminophospholipid translocase belongs to this new subfamily, suggesting that other subfamily members may transport other lipids or lipid-like molecules from one leaflet of the membrane bilayer to the other.

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Citations

Oct 4, 2000·Physiological Genomics·M S HalleckR A Schlegel
Oct 16, 2010·The Journal of Biological Chemistry·Lieke M van der VeldenStan F J van de Graaf
Oct 1, 2013·Pflügers Archiv : European journal of physiology·Rosa L Lopez-MarquesThomas Günther Pomorski
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