Multiple Microelectrode Recordings in STN-DBS Surgery for Parkinson's Disease: A Randomized Study

Movement Disorders Clinical Practice
Silje BjerknesInger Marie Skogseid

Abstract

Subthalamic nucleus deep brain stimulation improves motor symptoms and fluctuations in advanced Parkinson's disease, but the degree of clinical improvement depends on accurate anatomical electrode placement. Methods used to localize the sensory-motor part of the nucleus vary substantially. Using microelectrode recordings, at least three inserted microelectrodes are needed to obtain a three-dimensional map. Therefore, multiple simultaneously inserted microelectrodes should provide better guidance than single sequential microelectrodes. We aimed to compare the use of multiple simultaneous versus single sequential microelectrode recordings on efficacy and safety of subthalamic nucleus stimulation. Sixty patients were included in this double-blind, randomized study, 30 in each group. Primary outcome measures were the difference from baseline to 12 months in the MDS-UPDRS motor score (part III) in the off-medication state and quality of life using the Parkinson's Disease Questionnaire-39 (PDQ-39) scores. The mean reduction of the MDS-UPDRS III off score was 35 (SD 12) in the group investigated with multiple simultaneous microelectrodes compared to 26 (SD 10) in the single sequential microelectrode group (p = 0.004). The PDQ-39 Summa...Continue Reading

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Citations

Feb 23, 2020·Acta Neurologica Scandinavica·Terje NomeEspen Dietrichs
Apr 5, 2019·Therapeutic Advances in Neurological Disorders·Christian J HartmannAlfons Schnitzler
Aug 23, 2020·Brain Sciences·Jesús Pastor, Lorena Vega-Zelaya
Oct 22, 2020·NPJ Parkinson's Disease·Silje BjerknesMathias Toft
Jan 27, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Paresh K DoshiDeepak Das
Oct 15, 2020·Journal of Neural Engineering·Matteo VissaniAlberto Mazzoni

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Methods Mentioned

BETA
MDS

Clinical Trials Mentioned

NCT00855621

Software Mentioned

Brainlab iPlan
Stimloc
SPSS Statistics

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