PMID: 7518060Feb 28, 1994Paper

Multiple mitogenic signalling pathways in chromaffin cells: a model for cell cycle regulation in the nervous system

Neuroscience Letters
A S TischlerV Cherington

Abstract

Adult rat chromaffin cells proliferate in vivo in response to neurally derived signals. Their proliferation in vitro is stimulated either by peptide growth factors or by activators of adenylate cyclase or protein kinase C that mimic the effects of neurotransmitters in adrenal medullary nerve endings. Differing susceptibilities to inhibitors and potentiators suggest that growth factors, cyclic AMP-dependent protein kinases and protein kinase C act via partially distinct and partially overlapping signalling pathways. Depolarization inhibits the mitogenic response to NGF, through a mechanism that apparently involves activation of voltage-gated calcium channels, while sparing the response to phorbol esters that activate PKC. Activators of adenylate cyclase also inhibit the response to NGF. The findings suggest that during normal development, neurally derived signals supersede growth factors in regulating proliferation of chromaffin cells by selectively inhibiting or co-opting portions of growth factor signalling pathways. This model might be generally applicable to the development of the nervous system.

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Jan 15, 1992·Biochemical and Biophysical Research Communications·T WatanabeM Fujino
Dec 1, 1992·Current Opinion in Cell Biology·C J PallenG R Guy
Jul 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A S TischlerJ C Riseberg
Oct 1, 1992·Molecular Microbiology·K Aktories, A Wegner
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M C NowyckyR W Tsien
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A S TischlerR A DeLellis
Oct 17, 1985·Nature·L E Lillien, P Claude
May 15, 1968·Experientia·G MalvaldiM P Viola-Magni

❮ Previous
Next ❯

Citations

Jul 17, 2001·Journal of Cellular Biochemistry. Supplement·J F PowersA S Tischler
Mar 1, 1996·Progress in Neurobiology·K Unsicker, K Krieglstein
Sep 12, 2009·Critical Reviews in Toxicology·Helmut GreimHeinz-Walter Thielmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
A S TischlerR A DeLellis
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
A S TischlerJ C Riseberg
© 2021 Meta ULC. All rights reserved