PMID: 9426704Jan 14, 1998Paper

Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model

International Journal of Cancer. Journal International Du Cancer
S DiasF Balkwill

Abstract

IL-12 treatment of a murine transplantable breast carcinoma (HTH-K) led to tumour regression and cure which was related to the duration of treatment. We studied the sequential molecular and phenotypic changes in IL-12-treated tumours. IFN-gamma mRNA was detected 8 hr after the first treatment. mRNA expression for the IFN-gamma-inducible genes beta 2-microglobulin and indoleamine dioxygenase (IDO) was induced subsequently, together with the chemokine IP-10. IL-12-treated tumours had an abundant cellular infiltrate, consisting mainly of CD8+ T cells. mRNA for granzyme B and perforin also could be detected, suggesting that those cells were activated. After 7 days of daily therapy, tumours in IL-12-treated mice had a significant reduction in vasculature. Finally, the number of apoptotic tumour cells increased throughout IL-12 treatment. We compared the anti-tumour effects of IL-12 to those induced by IFN-gamma therapy, which caused initial tumour stasis but subsequent tumour progression. IFN-gamma induced beta 2-microglobulin and IDO over a 7-day period, but IP-10 was induced only transiently. IFN-gamma caused a lesser cellular infiltrate, a minor anti-angiogenic effect and a transient apoptotic effect. The success of IL-12 may be ...Continue Reading

References

Apr 7, 1995·Cell·G Berke
Apr 19, 1995·Journal of the National Cancer Institute·E E VoestJ Folkman
Feb 1, 1995·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·M J BrundaM K Gately
Jan 3, 1995·International Journal of Cancer. Journal International Du Cancer·F BurkeF R Balkwill
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J U Gutterman
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·M J BrundaA V Palleroni
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C SgadariG Tosato
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BurkeF R Balkwill

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Citations

May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T V LeeC G Ioannides
Jun 25, 2002·Expert Opinion on Biological Therapy·Jon M Wigginton, Robert H Wiltrout
Oct 2, 2001·Cancer Investigation·S DiasS Rafii
Jun 10, 2004·Experimental Dermatology·Johanna KeyserKarin Moelling
Mar 29, 2014·Proteomics. Clinical Applications·Lars T Joeckel, Phillip I Bird
Jun 2, 2000·Protein Expression and Purification·T K LittlejohnR J Truscott
May 18, 2000·Cancer Treatment Reviews·D YipP G Harper
Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·S DiasF Balkwill
Oct 8, 2005·Angiogenesis·Charlotta Dabrosin
Sep 28, 2004·The Journal of Biological Chemistry·Subhradip KarmakarChandana Das
May 27, 2003·The Journal of Biological Chemistry·Tamantha K LittlejohnMark J Walker

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