Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets

Frontiers in Oncology
Giuseppe PalmieriAntonio Cossu

Abstract

Molecular mechanisms involved in pathogenesis of malignant melanoma have been widely studied and novel therapeutic treatments developed in recent past years. Molecular targets for therapy have mostly been recognized in the RAS-RAF-MEK-ERK and PI3K-AKT signaling pathways; small-molecule inhibitors were drawn to specifically target key kinases. Unfortunately, these targeted drugs may display intrinsic or acquired resistance and various evidences suggest that inhibition of a single effector of the signal transduction cascades involved in melanoma pathogenesis may be ineffective in blocking the tumor growth. In this sense, a wider comprehension of the multiple molecular alterations accounting for either response or resistance to treatments with targeted inhibitors may be helpful in assessing, which is the most effective combination of such therapies. In the present review, we summarize the known molecular mechanisms underlying either intrinsic and acquired drug resistance either alternative roads to melanoma pathogenesis, which may become targets for innovative anticancer approaches.

References

Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Nov 26, 2002·Nature Genetics·Pamela M PollockPaul S Meltzer
Jan 2, 2003·Nature Reviews. Cancer·Julian Downward
May 28, 2003·Nature·Diego Loayza, Titia De Lange
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reuben J ShawLewis C Cantley
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Claudia WellbrockRichard Marais
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins
Apr 22, 2005·Biological Chemistry·Klaudia Giehl
Apr 28, 2005·Current Biology : CB·Daniel J Klionsky
May 17, 2005·Pigment Cell Research·Glen M BoylePeter G Parsons
Aug 5, 2005·Nature·Chrysiis MichaloglouDaniel S Peeper
Nov 18, 2005·The New England Journal of Medicine·John A CurtinBoris C Bastian
Jan 19, 2006·The Journal of Investigative Dermatology·Vikas K GoelFrank G Haluska
Mar 29, 2006·Melanoma Research·Nancy E Thomas
Aug 11, 2006·Trends in Molecular Medicine·Carmit LevyDavid E Fisher
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Jesús Gil, Gordon Peters
Feb 1, 2007·Journal of Clinical Pathology·Weifen F ZengRobert J Weil
Oct 3, 2007·Nature Cell Biology·Zhiping Xie, Daniel J Klionsky
Nov 6, 2007·Journal of Cellular and Molecular Medicine·G PalmieriA Cossu
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Feb 5, 2008·Cancer Research·Keith S HoekReinhard Dummer
Jul 17, 2008·Pigment Cell & Melanoma Research·Satoru YokoyamaDavid E Fisher
Jul 30, 2008·Biochimica Et Biophysica Acta·Gerben Vader, Susanne M A Lens
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Sep 3, 2008·Pigment Cell & Melanoma Research·Neil F Box, Tamara Terzian
Sep 16, 2008·Molecular Cancer Therapeutics·Keiran S M SmalleyKatherine L Nathanson
Sep 18, 2008·Cancer Investigation·Nandita SaxenaRajendra Prasad Tripathi
Sep 23, 2008·Cell Death and Differentiation·M C MaiuriG Kroemer
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol BeadlingChristopher L Corless
Dec 17, 2008·Nature·Catherine D Van RaamsdonkBoris C Bastian
Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mohammed Kashani-SabetRichard W Sagebiel
Jul 3, 2009·The Journal of Investigative Dermatology·Keiran S M Smalley
Jul 9, 2009·Human Genetics·Kathrine Damm Meyle, Per Guldberg
Sep 16, 2009·Journal of the National Cancer Institute·Jingrong LinToshiaki Saida
Oct 16, 2009·Journal of Translational Medicine·Giuseppe PalmieriPaolo A Ascierto
Nov 11, 2009·Molecular and Cellular Biology·Kian-Huat LimChristopher M Counter
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak

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Citations

Jun 7, 2016·The Journal of Investigative Dermatology·Milena CasulaUNKNOWN Italian Melanoma Intergroup (IMI)
Mar 28, 2017·International Journal of Dermatology·Giuliana OnnisRosanna Satta
Apr 22, 2017·Cancers·Mariana ToricelliMiriam G Jasiulionis
Sep 11, 2018·Future Oncology·Simone RiberoPietro Quaglino
Sep 16, 2018·Current Oncology Reports·Giuseppe PalmieriUNKNOWN Italian Melanoma Intergroup (IMI)
Feb 13, 2019·Medicina·Maria Maddalena SimilePanagiotis Paliogiannis
Oct 8, 2019·Cancer Medicine·Prisca BustamanteJulia V Burnier
Mar 2, 2018·Oncotarget·Maria Cristina SiniGiuseppe Palmieri
Dec 30, 2017·Oncotarget·Anna PassarelliFrancesco Silvestris
Jun 30, 2018·International Journal of Oncology·Federica FratangeloMaria Letizia Motti
Sep 7, 2019·Metallomics : Integrated Biometal Science·Marina PisanoCarla Rozzo
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haet Nim LimHye Jin Jung
Jul 2, 2020·International Journal of Molecular Sciences·Maria Letizia MottiMaria Vincenza Carriero
Aug 6, 2020·Journal of Clinical Medicine·Maria ColombinoGiuseppe Palmieri
Aug 29, 2019·Journal of Translational Medicine·Antonella MancaUNKNOWN Italian Melanoma Intergroup (IMI)
May 30, 2019·Nutrition & Metabolism·Maria Neve OmbraUNKNOWN Italian Melanoma Intergroup (IMI)
Oct 5, 2019·Journal of Clinical Medicine·Maria ColombinoGiuseppe Palmieri
Nov 13, 2019·BMC Pulmonary Medicine·Maria ColombinoGiuseppe Palmieri
Aug 7, 2019·BMC Cancer·Milena CasulaUNKNOWN Italian Melanoma Intergroup (IMI)
Feb 26, 2016·Journal of Translational Medicine·Federica FelicettiAlessandra Carè
Dec 2, 2020·International Journal of Molecular Sciences·Olamide T OlaobaEstelle Leclerc
Nov 2, 2019·Gene·Saif F KhanSharon Prince
May 24, 2020·The Journal of Surgical Research·Kimberly LooJeffrey M Farma
Mar 23, 2021·Frontiers in Molecular Biosciences·Simona De SummaRosamaria Pinto
Oct 23, 2020·Redox Biology·Liaisan R Arslanbaeva, Massimo M Santoro
Jun 3, 2021·International Journal of Molecular Sciences·Marina PisanoCarla Rozzo
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miroslawa CichorekIwona Pelikant-Malecka
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vijay Sagar MadamsettySudip Mukherjee
Sep 3, 2021·Developmental Cell·Meng-Yen LiElena Ezhkova

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Methods Mentioned

BETA
xenograft
biopsies

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