Multiple myeloma in old people : Practical skills for geriatricians and general practitioners

Zeitschrift für Gerontologie und Geriatrie
Valentin Goede

Abstract

Multiple myeloma is an age-associated disease. In aged and multimorbid patients the diagnosis could be delayed due to the diversity of symptoms of this disease. Key diagnostic steps are the detection of an M protein as a surrogate of clonal plasma cell proliferation and evaluation of the CRAB criteria (hypercalcemia, renal insufficiency, anemia, bone lesions). The individual prognosis and vulnerability to treatment complications can be assessed by use of validated scores. Following the introduction of many new drugs, vulnerable aged patients with multiple myeloma can also be very effectively treated with modern (partially chemotherapy-free) combination treatment and additional supportive care. Successful management of aged and multimorbid patients with multiple myeloma is not the sole task of the treating hemato-oncologist but also mostly requires the inclusion of general practitioners and geriatricians.

References

Aug 30, 2008·The New England Journal of Medicine·Jesús F San MiguelUNKNOWN VISTA Trial Investigators
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cyrille HulinPhilippe Moreau
Jun 18, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L DecosterM Extermann
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans WildiersArti Hurria
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel
Aug 5, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio PalumboPhilippe Moreau
Mar 10, 2017·Blood·Michel Delforge, Heinz Ludwig
Jun 24, 2017·Cancer Medicine·Henrik GregersenTobias Wirenfeldt Klausen
Aug 2, 2017·Current Opinion in Oncology·Sonja ZweegmanUNKNOWN EHA SWG on ‘Aging and Hematology’
Sep 28, 2017·Oncotarget·Alessandra LaroccaMario Boccadoro
Dec 13, 2017·The New England Journal of Medicine·María-Victoria MateosUNKNOWN ALCYONE Trial Investigators
May 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Supriya G MohileArti Hurria
Oct 10, 2018·American Journal of Hematology·Neeraj Y SainiMuzaffar H Qazilbash
Dec 12, 2018·Der Internist·L Rasche, N Weinhold
Apr 2, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph MikhaelTom Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Seminars in Oncology Nursing
C A Sheridan
Nihon rinsho. Japanese journal of clinical medicine
Journal of the American Academy of Nurse Practitioners
Colleen Dvorak
© 2021 Meta ULC. All rights reserved