PMID: 9540760Apr 16, 1998Paper

Multiple myeloma in younger patients: the role of age as prognostic factor

Annals of Hematology
A CorsoC Bernasconi

Abstract

The presenting features of 356 previously untreated multiple myeloma (MM) patients grouped according to age were analyzed in order (a) to elucidate the possible differences in initial clinical and laboratory features between patients younger than 50 years and the older ones and (b) to statistically assess the prognostic value of the parameters considered, with particular emphasis on the prognostic impact of age. Patients were divided into two groups: group I included 61 patients aged less than 50, group II comprised 295 patients aged 50 or more. No significant differences were found between the two groups in terms of either clinical or laboratory initial characteristics. The treatments adopted and the response to therapy did not differ in the two groups. The prognostic value of presenting features was evaluated for the whole cohort by univariate and multivariate analysis, considering both the observed survival rates and survival rates corrected for the effect of other independent causes of death, using a Poisson model. In both models, calcium level (RR 2.33), performance status (RR 1.83), and creatinine (RR 1.69) maintained their independent negative prognostic value. In contrast, the impact of age was different in the two mode...Continue Reading

Citations

Sep 16, 2008·Clinical and Experimental Medicine·Francesca MerchionneFranco Dammacco
Jul 10, 1999·Current Opinion in Hematology·K R DesikanB Barlogie
Jun 13, 2008·Onkologie·Martin GörnerUNKNOWN Task Force Geriatrische Onkologie of the DGHO, OGHO, DGG and AIO
Sep 28, 2007·Drugs & Aging·Hang QuachLinda Mileshkin
Feb 22, 2014·Case Reports in Nephrology·Hasan J SalamehTina Kochar
Dec 29, 2004·Leukemia & Lymphoma·Kazuyuki ShimizuUNKNOWN Japan Myeloma Study Group
Jul 16, 2005·Leukemia & Lymphoma·Linda Mileshkin, H Miles Prince
Nov 9, 2011·Clinical Lymphoma, Myeloma & Leukemia·Sascha A Tuchman, Sagar Lonial
Jun 27, 2017·The Korean Journal of Internal Medicine·Junghoon ShinInho Kim

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