Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature

Journal of Oncology
Gergely VargaTamás Masszi

Abstract

Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment. Recent case reports show promising effectivity of pomalidomide and marizomib.

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Citations

Nov 5, 2019·Expert Review of Anticancer Therapy·Evangelos Eleutherakis-PapaiakovouMeletios A Dimopoulos
Mar 10, 2021·British Journal of Haematology·Alexis ClaudelBertrand Arnulf
Mar 1, 2021·Clinical Imaging·Ernest Junrui LimChi Long Ho
Jun 12, 2021·Pediatric Blood & Cancer·Clay M HoerigDaniela A Bota
Feb 2, 2022·Clinical Chemistry·Zhicheng JinXin Yi

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Methods Mentioned

BETA
electrophoresis
flow cytometry
biopsy
flow

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